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dc.contributor.authorGraham, G.en_US
dc.contributor.authorWhitehouse, Michaelen_US
dc.contributor.authorBushell, Gillianen_US
dc.date.accessioned2017-05-03T17:00:09Z
dc.date.available2017-05-03T17:00:09Z
dc.date.issued2008en_US
dc.date.modified2010-08-30T07:02:11Z
dc.identifier.issn09254692en_US
dc.identifier.doi10.1007/s10787-007-0020-yen_AU
dc.identifier.urihttp://hdl.handle.net/10072/26830
dc.description.abstractThe aurocyanide anion, Au(CN) 2- , is a human metabolite of several anti-rheumatic gold complexes containing monovalent gold (I) bound to a sulphur ligand. This article reviews some of the chemical and pharmacological properties of this intriguing metabolite, and reports its anti-arthritic and anti-inflammatory activity in rats. Au(CN) 2- is generated from the therapeutic gold complexes by small amounts of hydrogen cyanide, HCN, produced from thiocyanate, SCN-, by myeloperoxidase (MPO) an enzyme in neutrophils which normally produces hypochlorite, OCl-. Thus, Au(CN) 2- is formed at sites of inflammation where activated neutrophils are present. This includes atherosclerotic lesions as well as inflamed joints. MPO also oxidises Au(CN) 2- to Au(III) complexes such as Au(CN) 4- . Au(CN) 2- is normally a very stable monovalent gold complex. In a biological context, only low concentrations are ever present at both extracellular and intracellular sites. However, Au(CN) 2- produced locally may facilitate the cellular uptake and hence the therapeutic and toxic effects of gold drugs. Au(CN) 2- may also be involved in a redox cycle where Au(CN) 2- is oxidised to Au(CN) 4- which is, in turn, reduced back to Au(CN) 2- by endogenous thiols. There are still many questions to be resolved concerning Au(CN) 2- including its intrinsic toxicity and the extent to which it may contribute to the overall anti-arthritic activities of the gold-thiolates from which it is formed in vivo.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_AU
dc.languageEnglishen_US
dc.language.isoen_AU
dc.publisherBirkhaeuser Verlag AGen_US
dc.publisher.placeSwitzerlanden_US
dc.relation.ispartofstudentpublicationNen_AU
dc.relation.ispartofpagefrom126en_US
dc.relation.ispartofpageto132en_US
dc.relation.ispartofissue3en_US
dc.relation.ispartofjournalInflammopharmacologyen_US
dc.relation.ispartofvolume16en_US
dc.rights.retentionYen_AU
dc.subject.fieldofresearchMulti-Disciplinaryen_US
dc.subject.fieldofresearchcode999999en_US
dc.titleAurocyanide, dicyano-aurate (I), a pharmacologically active metabolite of medicinal gold complexesen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.date.issued2008
gro.hasfulltextNo Full Text


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