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  • Physiological role of carnosine in contracting muscle

    Author(s)
    Begum, Gulshanara
    Cunliffe, Adam
    Leveritt, Michael
    Griffith University Author(s)
    Leveritt, Michael
    Year published
    2005
    Metadata
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    Abstract
    High-intensity exercise leads to reductions in muscle substrates (ATP, PCr6, and glycogen) and a subsequent accumulation of metabolites (ADP, P, H(+), and Mg(+)) with a possible increase in free radical production. These factors independently and collectively have deleterious effects on muscle, with significant repercussions on high-intensity performance or training sessions. The effect of carnosine on overcoming muscle fatigue appears to be related to its ability to buffer the increased H(+) concentration following high-intensity work. Carnosine, however, has other roles such as an antioxidant, a metal chelator, a Ca(2+) ...
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    High-intensity exercise leads to reductions in muscle substrates (ATP, PCr6, and glycogen) and a subsequent accumulation of metabolites (ADP, P, H(+), and Mg(+)) with a possible increase in free radical production. These factors independently and collectively have deleterious effects on muscle, with significant repercussions on high-intensity performance or training sessions. The effect of carnosine on overcoming muscle fatigue appears to be related to its ability to buffer the increased H(+) concentration following high-intensity work. Carnosine, however, has other roles such as an antioxidant, a metal chelator, a Ca(2+) and enzyme regulator, an inhibitor of protein glycosylation and protein-protein cross-linking. To date7comma; only 1 study has investigated the effects of carnosine supplementation (not in pure form) on exercise performance in human subjects and found no improvement in repetitive high-intensity work. Much data has come from in vitro work on animal skeletal muscle fibers or other components of muscle contractile mechanisms. Thus further research needs to be carried out on humans to provide additional understanding on the effects of carnosine in vivo.
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    Journal Title
    International Journal of Sport Nutrition and Exercise Metabolism
    Volume
    15
    Issue
    5
    Publisher URI
    http://journals.humankinetics.com/IJSNEM
    Subject
    Human Movement and Sports Sciences
    Medical Physiology
    Publication URI
    http://hdl.handle.net/10072/26833
    Collection
    • Journal articles

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