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dc.contributor.authorNikles, CJ
dc.contributor.authorYelland, M
dc.contributor.authorDel Mar, C
dc.contributor.authorWilkinson, D
dc.date.accessioned2017-05-03T15:05:58Z
dc.date.available2017-05-03T15:05:58Z
dc.date.issued2005
dc.identifier.issn1075-2765
dc.identifier.urihttp://hdl.handle.net/10072/26844
dc.description.abstractChronic pain is a significant public health burden. Several international guidelines and influential reviews recommend the use of paracetamol (acetaminophen) as the first-line analgesic of choice for the management of chronic pain. These recommendations are based largely on the balance of evidence, which favorably demonstrates the efficacy, safety, and low cost of paracetamol relative to other analgesics. A decade ago, March et al suggested that because of the dangers associated with conventional nonsteroidal antiinflammatory (NSAID) use, particularly in the elderly, they should ideally not be used without an individual n-of-1 trial to show that they are more effective than paracetamol. Today, the results of our investigations into the individualization of pain management options continue to support this suggestion. Based on the data available to date, it still seems prudent to use NSAIDs only in those patients in whom there is good evidence of improved efficacy over paracetamol. In patients with chronic pain, paracetamol can play an important role as an NSAID sparer, with resultant benefits in terms of reduced adverse effects and cost savings.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherLippincott Williams & Wilkins
dc.publisher.placeUnited States of America
dc.publisher.urihttp://journals.lww.com/americantherapeutics/Abstract/2005/01000/The_Role_of_Paracetamol_in_Chronic_Pain__An.11.aspx
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom80
dc.relation.ispartofpageto91
dc.relation.ispartofissue1
dc.relation.ispartofjournalAmerican Journal of Therapeutics
dc.relation.ispartofvolume12
dc.rights.retentionY
dc.subject.fieldofresearchPublic Health and Health Services
dc.subject.fieldofresearchcode1117
dc.titleThe Role of Paracetamol in Chronic Pain: An Evidence-Based Approach
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.date.issued2015-02-05T03:42:57Z
gro.hasfulltextNo Full Text
gro.griffith.authorYelland, Michael


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