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dc.contributor.authorEkberg, J
dc.contributor.authorCraik, DJ
dc.contributor.authorAdams, DJ
dc.date.accessioned2017-05-03T16:58:38Z
dc.date.available2017-05-03T16:58:38Z
dc.date.issued2008
dc.date.modified2009-11-25T07:59:31Z
dc.identifier.issn1357-2725
dc.identifier.doi10.1016/j.biocel.2007.08.017
dc.identifier.urihttp://hdl.handle.net/10072/26884
dc.description.abstractThe rising phase of the action potential in excitable cells is mediated by voltage-gated sodium channels (VGSCs), of which there are nine mammalian subtypes with distinct tissue distribution and biophysical properties. The involvement of certain VGSC subtypes in disease states such as pain and epilepsy highlights the need for agents that modulate VGSCs in a subtype-specific manner. Conotoxins from marine snails of the Conus genus constitute a promising source of such modulators, since these peptide toxins have evolved to become selective for various membrane receptors, ion channels and transporters in excitable cells. This review covers the structure and function of three classes of conopeptides that modulate VGSCs: the pore-blocking 季onotoxins, the d-conotoxins which delay or inhibit VGSC inactivation, and the 叭conotoxins which inhibit VGSC Na+ conductance independent of the tetrodotoxin binding site. Some of these toxins have potential therapeutic and research applications, in particular the 叭conotoxins, which may develop into potential drug leads for the treatment of pain states.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier
dc.publisher.placeUnited States of America
dc.publisher.urihttp://www.elsevier.com/locate/biocel
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom2363
dc.relation.ispartofpageto2368
dc.relation.ispartofissue11
dc.relation.ispartofjournalThe International Journal of Biochemistry and Cell Biology
dc.relation.ispartofvolume40
dc.rights.retentionY
dc.subject.fieldofresearchCellular Nervous System
dc.subject.fieldofresearchBiochemistry and Cell Biology
dc.subject.fieldofresearchMedical Biochemistry and Metabolomics
dc.subject.fieldofresearchMedical Physiology
dc.subject.fieldofresearchcode110902
dc.subject.fieldofresearchcode0601
dc.subject.fieldofresearchcode1101
dc.subject.fieldofresearchcode1116
dc.titleConotoxin modulation of voltage-gated sodium channels
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.date.issued2008
gro.hasfulltextNo Full Text
gro.griffith.authorEkberg, Jenny A.


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