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  • Health benefits of a natural carotenoid rich oil: a proposed mechanism of protection against ischaemi/reperfusion injury

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    Author(s)
    Van Rooyen, J
    Esterhuyse, AJ
    Engelbrecht, AM
    Du Toit, EF
    Griffith University Author(s)
    Du Toit, Eugene
    Year published
    2008
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    Abstract
    Numerous studies have reported the protective properties of carotenoid supplementation against skin and eye associated diseases. However, conflicting data concerning the efficacy of ߭carotene in the pathogenesis of cancers and cardiovascular disease exist. It has been shown that ߭carotene is an effective antioxidant on its own or in combination with other antioxidants. Red palm oil (RPO) is a potent anti-oxidant rich oil which consists of carotenoids, tocopherols, tocotrienols and lycopenes as well as lipid fractions such as squalene, saturated and unsaturated fatty acids (which maximize absorption of these anti-oxidants) ...
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    Numerous studies have reported the protective properties of carotenoid supplementation against skin and eye associated diseases. However, conflicting data concerning the efficacy of ߭carotene in the pathogenesis of cancers and cardiovascular disease exist. It has been shown that ߭carotene is an effective antioxidant on its own or in combination with other antioxidants. Red palm oil (RPO) is a potent anti-oxidant rich oil which consists of carotenoids, tocopherols, tocotrienols and lycopenes as well as lipid fractions such as squalene, saturated and unsaturated fatty acids (which maximize absorption of these anti-oxidants) and Co-enzyme Q10. a and ߭carotene account for more than 90% of the total carotene in RPO. It is known that ischaemia/reperfusion-induced injury causes an imbalance in oxygen supply which can lead to oxidative stress in the heart. It has been shown that the mitogen-activated protein kinases (MAPKs), PKB/Akt and the NO-cGMP all play vital roles in ischaemia/ reperfusion injury in the heart. Therefore, our review mainly focuses on the signaling pathways involved in functional recovery induced by a natural carotenoid oil after ischaemia/reperfusion injury
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    Journal Title
    Asia Pacific Journal of Clinical Nutrition
    Volume
    17
    Publisher URI
    http://apjcn.nhri.org.tw/server/APJCN/17%20Suppl%201/abstracts.php
    Copyright Statement
    © 2008 HEC Press. The attached file is reproduced here in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version.
    Subject
    Cardiology (incl. cardiovascular diseases)
    Nutrition and dietetics
    Publication URI
    http://hdl.handle.net/10072/26917
    Collection
    • Journal articles

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