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dc.contributor.authorSaha, Sukanta
dc.contributor.authorChant, David
dc.contributor.authorWelham, Joy
dc.contributor.authorMcGrath, John
dc.date.accessioned2018-01-11T23:27:54Z
dc.date.available2018-01-11T23:27:54Z
dc.date.issued2005
dc.date.modified2009-12-02T22:02:38Z
dc.identifier.issn15491277
dc.identifier.doi10.1371/journal.pmed.0020141
dc.identifier.urihttp://hdl.handle.net/10072/27027
dc.description.abstractBackground Understanding the prevalence of schizophrenia has important implications for both health service planning and risk factor epidemiology. The aims of this review are to systematically identify and collate studies describing the prevalence of schizophrenia, to summarize the findings of these studies, and to explore selected factors that may influence prevalence estimates. Methods and Findings Studies with original data related to the prevalence of schizophrenia (published 1965-2002) were identified via searching electronic databases, reviewing citations, and writing to authors. These studies were divided into "core" studies, "migrant" studies, and studies based on "other special groups." Between- and within-study filters were applied in order to identify discrete prevalence estimates. Cumulative plots of prevalence estimates were made and the distributions described when the underlying estimates were sorted according to prevalence type (point, period, lifetime, and lifetime morbid risk). Based on combined prevalence estimates, the influence of selected key variables was examined (sex, urbanicity, migrant status, country economic index, and study quality). A total of 1,721 prevalence estimates from 188 studies were identified. These estimates were drawn from 46 countries, and were based on an estimated 154,140 potentially overlapping prevalent cases. We identified 132 core studies, 15 migrant studies, and 41 studies based on other special groups. The median values per 1,000 persons (10%-90% quantiles) for the distributions for point, period, lifetime, and lifetime morbid risk were 4.6 (1.9-10.0), 3.3 (1.3-8.2), 4.0 (1.6-12.1), and 7.2 (3.1-27.1), respectively. Based on combined prevalence estimates, we found no significant difference (a) between males and females, or (b) between urban, rural, and mixed sites. The prevalence of schizophrenia in migrants was higher compared to native-born individuals: the migrant-to-native-born ratio median (10%-90% quantile) was 1.8 (0.9-6.4). When sites were grouped by economic status, prevalence estimates from "least developed" countries were significantly lower than those from both "emerging" and "developed" sites (p = 0.04). Studies that scored higher on a quality score had significantly higher prevalence estimates (p = 0.02). Conclusions There is a wealth of data about the prevalence of schizophrenia. These gradients, and the variability found in prevalence estimate distributions, can provide direction for future hypothesis-driven research.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoen_AU
dc.publisherPublic Library of Science
dc.publisher.placeUS
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom0413
dc.relation.ispartofpageto0433
dc.relation.ispartofissue5
dc.relation.ispartofjournalPLoS Medicine
dc.relation.ispartofvolume2
dc.rights.retentionY
dc.subject.fieldofresearchEpidemiology
dc.subject.fieldofresearchMedical and Health Sciences
dc.subject.fieldofresearchcode111706
dc.subject.fieldofresearchcode11
dc.titleA Systematic Review of the Prevalence of Schizophrenia
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dcterms.licensehttps://creativecommons.org/licenses/by/4.0/
dc.description.versionPublished
gro.rights.copyright© 2005 Saha et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
gro.date.issued2005
gro.hasfulltextFull Text
gro.griffith.authorMcGrath, John J.


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