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dc.contributor.authorHolliday, Elizabeth G.
dc.contributor.authorHandoko, Herlina Y.
dc.contributor.authorJames, Michael R.
dc.contributor.authorMcGrath, John J.
dc.contributor.authorNertney, Deborah A.
dc.contributor.authorTirupati, Sujit
dc.contributor.authorThara, Rangaswamy
dc.contributor.authorLevinson, Douglas F.
dc.contributor.authorHayward, Nicholas K.
dc.contributor.authorMowry, Bryan J.
dc.contributor.authorNyholt, Dale R.
dc.date.accessioned2017-05-03T16:58:08Z
dc.date.available2017-05-03T16:58:08Z
dc.date.issued2006
dc.date.modified2009-12-05T05:15:06Z
dc.identifier.issn18324274
dc.identifier.doi10.1375/183242706778025035
dc.identifier.urihttp://hdl.handle.net/10072/27083
dc.description.abstractNumerous studies have reported association between variants in the dystrobrevin binding protein 1 (dysbindin) gene (DTNBP1) and schizophrenia. However, the pattern of results is complex and to date, no specific risk marker or haplotype has been consistently identified. The number of single nucleotide polymorphisms (SNPs) tested in these studies has ranged from 5 to 20. We attempted to replicate previous findings by testing 16 SNPs in samples of 41 Australian pedigrees, 194 Australian cases and 180 controls, and 197 Indian pedigrees. No globally significant evidence for association was observed in any sample, despite power calculations indicating sufficient power to replicate several previous findings. Possible explanations for our results include sample differences in background linkage disequilibrium and/or risk allele effect size, the presence of multiple risk alleles upon different haplotypes, or the presence of a single risk allele upon multiple haplotypes. Some previous associations may also represent false positives. Examination of Caucasian HapMap phase II genotype data spanning the DTNBP1 region indicates upwards of 40 SNPs are required to satisfactorily assess all nonredundant variation within DTNBP1 and its potential regulatory regions for association with schizophrenia. More comprehensive studies in multiple samples will be required to determine whether specific DTNBP1 variants function as risk factors for schizophrenia.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherAustralian Academic Press
dc.publisher.placeAustralia
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom531
dc.relation.ispartofpageto539
dc.relation.ispartofissue4
dc.relation.ispartofjournalTwin Research and Human Genetics
dc.relation.ispartofvolume9
dc.rights.retentionY
dc.subject.fieldofresearchPsychiatry (incl. Psychotherapy)
dc.subject.fieldofresearchClinical Sciences
dc.subject.fieldofresearchPaediatrics and Reproductive Medicine
dc.subject.fieldofresearchCognitive Sciences
dc.subject.fieldofresearchcode110319
dc.subject.fieldofresearchcode1103
dc.subject.fieldofresearchcode1114
dc.subject.fieldofresearchcode1702
dc.titleAssociation study of the dystrobrevin-binding gene with schizophrenia in Australian and Indian samples
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.date.issued2006
gro.hasfulltextNo Full Text
gro.griffith.authorMcGrath, John J.


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