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  • Polymorphisms in the vitamin D receptor and their associations with risk of schizophrenia and selected anthropometric measures

    Author(s)
    Handoko, H.
    Nancarrow, D.
    Mowry, B.
    McGrath, J.
    Griffith University Author(s)
    McGrath, John J.
    Year published
    2006
    Metadata
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    Abstract
    The association between vitamin D levels and skeletal growth has long been recognized. However, exposure to low levels of vitamin D during early life is also known to alter brain development, and is a candidate risk factor for schizophrenia. This study examines the association between four polymorphisms in the vitamin D receptor (VDR) and 1) risk of schizophrenia, and 2) three anthropometric variables (height, head size, and head shape). Four single-nucleotide polymorphisms (SNPs; rs10735810/FokI, rs1544410/BsmI, rs7975232/ApaI, and rs731236/TaqI) in the VDR gene were genotyped in 179 individuals with schizophrenia and 189 ...
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    The association between vitamin D levels and skeletal growth has long been recognized. However, exposure to low levels of vitamin D during early life is also known to alter brain development, and is a candidate risk factor for schizophrenia. This study examines the association between four polymorphisms in the vitamin D receptor (VDR) and 1) risk of schizophrenia, and 2) three anthropometric variables (height, head size, and head shape). Four single-nucleotide polymorphisms (SNPs; rs10735810/FokI, rs1544410/BsmI, rs7975232/ApaI, and rs731236/TaqI) in the VDR gene were genotyped in 179 individuals with schizophrenia and 189 healthy controls. No significant associations were detected between any of the four VDR SNPs and risk of schizophrenia. Patients were slightly but significantly shorter compared to controls. Of the four SNPs, only rs10735810/FokI was associated with any of the anthropometric measures: the M4 isoform of this SNP was significantly associated with larger head size (P = 0.002). In light of the evidence demonstrating a role for vitamin D during brain development, the association between polymorphisms in VDR and brain development warrants closer scrutiny.
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    Journal Title
    American Journal of Human Biology
    Volume
    18
    Issue
    3
    DOI
    https://doi.org/10.1002/ajhb.20504
    Subject
    Medical Biochemistry and Metabolomics not elsewhere classified
    Evolutionary Biology
    Nutrition and Dietetics
    Anthropology
    Publication URI
    http://hdl.handle.net/10072/27091
    Collection
    • Journal articles

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