The romance of balancing selection versus the sober alternatives: Let the data rule

Abstract

Schizophrenia has attracted more than its fair share of evolutionary-based theories. The theories involving balancing selection are based on the assumption that the incidence of schizophrenia is invariant across time and place. Modern epidemiology allows us to reject this dogmatic belief. Once variations in the genetic and epidemiological landscape of schizophrenia are acknowledged, more productive research models can be generated.