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dc.contributor.authorK. Pagan, Juliaen_US
dc.contributor.authorArnold, Jeremyen_US
dc.contributor.authorJ. Hanchard, Kimen_US
dc.contributor.authorKumar, Ramanen_US
dc.contributor.authorBruno, Tizianaen_US
dc.contributor.authorJ. K. Jones, Mathewen_US
dc.contributor.authorJ. Richard, Dereken_US
dc.contributor.authorForrest, Alistairen_US
dc.contributor.authorSpurdle, Amandaen_US
dc.contributor.authorVerdin, Ericen_US
dc.contributor.authorCrossley, Merlinen_US
dc.contributor.authorFanciulli, Maurizioen_US
dc.contributor.authorChenevix-Trench, Georgiaen_US
dc.contributor.authorB. Young, Daviden_US
dc.contributor.authorKhanna, Kum Kumen_US
dc.date.accessioned2017-05-03T16:58:19Z
dc.date.available2017-05-03T16:58:19Z
dc.date.issued2007en_US
dc.date.modified2009-12-07T03:37:36Z
dc.identifier.issn00219258en_US
dc.identifier.doi10.1074/jbc.M700246200en_AU
dc.identifier.urihttp://hdl.handle.net/10072/27136
dc.description.abstractCorepressors play a crucial role in negative gene regulation and are defective in several diseases. BCoR is a corepressor for the BCL6 repressor protein. Here we describe and functionally characterize BCoR-L1, a homolog of BCoR. When tethered to a heterologous promoter, BCoR-L1 is capable of strong repression. Like other corepressors, BCoR-L1 associates with histone deacetylase (HDAC) activity. Specifically, BCoR-L1 coprecipitates with the Class II HDACs, HDAC4, HDAC5, and HDAC7, suggesting that they are involved in its role as a transcriptional repressor. BCoR-L1 also interacts with the CtBP corepressor through a CtBP-interacting motif in its amino terminus. Abrogation of the CtBP binding site within BCoR-L1 partially relieves BCoR-L1-mediated transcriptional repression. Furthermore, BCoR-L1 is located on the E-cadherin promoter, a known CtBP-regulated promoter, and represses the E-cadherin promoter activity in a reporter assay. The inhibition of BCoR-L1 expression by RNA-mediated interference results in derepression of E-cadherin in cells that do not normally express E-cadherin, indicating that BCoR-L1 contributes to the repression of an authentic endogenous CtBP target.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_AU
dc.languageEnglishen_US
dc.language.isoen_AU
dc.publisherAmerican Society for Biochemistry and Molecular Biologyen_US
dc.publisher.placeUSAen_US
dc.relation.ispartofstudentpublicationNen_AU
dc.relation.ispartofpagefrom15248en_US
dc.relation.ispartofpageto15257en_US
dc.relation.ispartofissue20en_US
dc.relation.ispartofjournalJournal of Biological Chemistryen_US
dc.relation.ispartofvolume282en_US
dc.rights.retentionYen_AU
dc.subject.fieldofresearchcode270199en_US
dc.titleA Novel Corepressor, BCoR-L1, Represses Transcription Through an Interaction with CtBPen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.date.issued2007
gro.hasfulltextNo Full Text


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