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dc.contributor.authorBecker, Axel
dc.contributor.authorW. Eyles, Darryl
dc.contributor.authorJ. McGrath, John
dc.contributor.authorGrecksch, Gisela
dc.date.accessioned2017-05-03T16:58:16Z
dc.date.available2017-05-03T16:58:16Z
dc.date.issued2005
dc.date.modified2009-12-07T03:38:32Z
dc.identifier.issn01664328
dc.identifier.doi10.1016/j.bbr.2005.02.015
dc.identifier.urihttp://hdl.handle.net/10072/27146
dc.description.abstractBased on clues from epidemiology, low prenatal vitamin D has been proposed as a candidate risk factor for schizophrenia. Recent animal experiments have demonstrated that transient prenatal vitamin D deficiency is associated with persistent alterations in brain morphology and neurotrophin expression. In order to explore the utility of the vitamin D animal model of schizophrenia, we examined different types of learning and memory in adult rats exposed to transient prenatal vitamin D deficiency. Compared to control animals, the prenatally deplete animals had a significant impairment of latent inhibition, a feature often associated with schizophrenia. In addition, the deplete group was (a) significantly impaired on hole board habituation and (b) significantly better at maintaining previously learnt rules of brightness discrimination in a Y-chamber. In contrast, the prenatally deplete animals showed no impairment on the spatial learning task in the radial maze, nor on two-way active avoidance learning in the shuttle-box. The results indicate that transient prenatal vitamin D depletion in the rat is associated with subtle and discrete alterations in learning and memory. The behavioural phenotype associated with this animal model may provide insights into the neurobiological correlates of the cognitive impairments of schizophrenia.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier
dc.publisher.placeNetherlands
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom306
dc.relation.ispartofpageto312
dc.relation.ispartofissue2
dc.relation.ispartofjournalBehavioural Brain Research
dc.relation.ispartofvolume161
dc.rights.retentionY
dc.subject.fieldofresearchNeurosciences not elsewhere classified
dc.subject.fieldofresearchMedical and Health Sciences
dc.subject.fieldofresearchPsychology and Cognitive Sciences
dc.subject.fieldofresearchcode110999
dc.subject.fieldofresearchcode11
dc.subject.fieldofresearchcode17
dc.titleTransient prenatal vitamin D deficiency is associated with subtle alterations in learning and memory functions in adult rats
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.date.issued2005
gro.hasfulltextNo Full Text
gro.griffith.authorMcGrath, John J.


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