α,β-Unsaturated δ-Lactones from Copper-Catalyzed Asymmetric Vinylogous Mukaiyama Reactions of Aldehydes: Scope and Mechanistic Insights
Author(s)
Bazán-Tejeda, Belén
Bluet, Guillaume
Broustal, Garance
Campagne, Jean-Marc
Griffith University Author(s)
Year published
2006
Metadata
Show full item recordAbstract
A direct regio-, diastereo-, and enantiocontrolled access to a,߭unsaturated d-lactones is described, based on the reaction of a silyl dienolate and an aldehyde in the presence of 10 % of Carreira's catalyst. The scope and limitations of this reaction, as well as mechanistic insights concerning the reactivity of an allyl copper species, are discussed.A direct regio-, diastereo-, and enantiocontrolled access to a,߭unsaturated d-lactones is described, based on the reaction of a silyl dienolate and an aldehyde in the presence of 10 % of Carreira's catalyst. The scope and limitations of this reaction, as well as mechanistic insights concerning the reactivity of an allyl copper species, are discussed.
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Journal Title
Chemistry : a European journal
Volume
12
Issue
32
Subject
Chemical Sciences