Stereocontrolled synthesis of (7E,9Z)-[9,10-2H]-conjugated linoleic acid
Author(s)
Broustal, Garance
Loreau, Olivier
Griffith University Author(s)
Year published
2004
Metadata
Show full item recordAbstract
To study the metabolism of minor conjugated linoleic acid isomers (CLAs), (7E,9Z)-[9,10-2H] CLA was prepared in three steps from a conjugated enyne precursor. In the labelling step, deuterium atoms were introduced by partial reduction of the triple bond using deuterated disiamylborane and acetic acid-d4. Deuterated (7E,9Z) CLA was obtained with high isotopic enrichment (>99%) and purity greater than 95%. Copyright 頲004 John Wiley & Sons, Ltd.To study the metabolism of minor conjugated linoleic acid isomers (CLAs), (7E,9Z)-[9,10-2H] CLA was prepared in three steps from a conjugated enyne precursor. In the labelling step, deuterium atoms were introduced by partial reduction of the triple bond using deuterated disiamylborane and acetic acid-d4. Deuterated (7E,9Z) CLA was obtained with high isotopic enrichment (>99%) and purity greater than 95%. Copyright 頲004 John Wiley & Sons, Ltd.
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Journal Title
Journal of Labelled Compounds and Radiopharmaceuticals
Volume
47
Issue
12
Subject
Organic Chemistry
Pharmacology and Pharmaceutical Sciences