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dc.contributor.authorW. Eyles, Darryl
dc.contributor.authorSmith, Steven
dc.contributor.authorKinobe, Robert
dc.contributor.authorHewison, Martin
dc.contributor.authorMcGrath, John J.
dc.date.accessioned2017-05-03T16:58:17Z
dc.date.available2017-05-03T16:58:17Z
dc.date.issued2005
dc.date.modified2009-12-07T03:41:44Z
dc.identifier.issn08910618
dc.identifier.doi10.1016/j.jchemneu.2004.08.006
dc.identifier.urihttp://hdl.handle.net/10072/27183
dc.description.abstractDespite a growing body of evidence that Vitamin D is involved in mammalian brain functioning, there has been a lack of direct evidence about its role in the human brain. This paper reports, for the first time, the distribution of the 1,25-dihydroxyvitamin D3 receptor (VDR), and 1a-hydroxylase (1a-OHase), the enzyme responsible for the formation of the active vitamin in the human brain. The receptor and the enzyme were found in both neurons and glial cells in a regional and layer-specific pattern. The VDR was restricted to the nucleus whilst 1a-OHase was distributed throughout the cytoplasm. The distribution of the VDR in human brain was strikingly similar to that reported in rodents. Many regions contained equivalent amounts of both the VDR and 1a-OHase, however the macrocellular cells within the nucleus basalis of Meynert (NBM) and the Purkinje cells in the cerebellum expressed 1a-OHase in the absence of VDR. The strongest immunohistochemical staining for both the receptor and enzyme was in the hypothalamus and in the large (presumably dopaminergic) neurons within the substantia nigra. The observed distribution of the VDR is consistent with the proposal that Vitamin D operates in a similar fashion to the known neurosteroids. The widespread distribution of 1a-OHase and the VDR suggests that Vitamin D may have autocrine/paracrine properties in the human brain.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier
dc.publisher.placeNetherlands
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom21
dc.relation.ispartofpageto30
dc.relation.ispartofissue1
dc.relation.ispartofjournalJournal of Chemical Neuroanatomy
dc.relation.ispartofvolume29
dc.rights.retentionY
dc.subject.fieldofresearchNeurosciences not elsewhere classified
dc.subject.fieldofresearchNeurosciences
dc.subject.fieldofresearchcode110999
dc.subject.fieldofresearchcode1109
dc.titleDistribution of the Vitamin D receptor and 1α-hydroxylase in human brain
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.date.issued2005
gro.hasfulltextNo Full Text
gro.griffith.authorMcGrath, John J.


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