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  • Effector function of leucocytes from susceptible and resistant mice against distinct isolates of Candida albicans

    Author(s)
    Hu, Yan
    Farah, Camile
    Ashman, Robert
    Griffith University Author(s)
    Ashman, Robert B.
    Year published
    2006
    Metadata
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    Abstract
    Neutrophils and macrophages were generated in vitro from mice that display either high or low tissue susceptibilities to Candida albicans infection and their ability to phagocytose and kill three isolates of the yeast with different virulence characteristics was evaluated. In the absence of opsonization, phagocytosis by BALB/c and CBA/CaH neutrophils was comparable, but the killing was very poor. Opsonization with normal serum slightly decreased phagocytosis, but it had markedly different effects on killing, either enhancing or inhibiting candidacidal activity, depending on the combination of yeast isolate and mouse strain. ...
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    Neutrophils and macrophages were generated in vitro from mice that display either high or low tissue susceptibilities to Candida albicans infection and their ability to phagocytose and kill three isolates of the yeast with different virulence characteristics was evaluated. In the absence of opsonization, phagocytosis by BALB/c and CBA/CaH neutrophils was comparable, but the killing was very poor. Opsonization with normal serum slightly decreased phagocytosis, but it had markedly different effects on killing, either enhancing or inhibiting candidacidal activity, depending on the combination of yeast isolate and mouse strain. In contrast, BALB/c macrophages showed high levels of phagocytosis and killing of both unopsonized yeasts and opsonized yeasts; whereas killing of unopsonized yeasts by CBA/CaH macrophages was poor, it was markedly enhanced by opsonization.
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    Journal Title
    Immunology and Cell Biology
    Volume
    84
    Issue
    5
    DOI
    https://doi.org/10.1111/j.1440-1711.2006.01457.x
    Subject
    Biochemistry and Cell Biology
    Immunology
    Publication URI
    http://hdl.handle.net/10072/27207
    Collection
    • Journal articles

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