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  • TNF and TNF receptor expression and insulin sensitivity in human omental and subcutaneous adipose tissue - influence of BMI and adipose distribution

    Author(s)
    Good, Manuela
    Newell, Felicity
    Haupt, Larisa
    Whitehead, Jonathan P.
    Hutley, Louise
    Prins, Johannes B.
    Griffith University Author(s)
    Haupt, Larisa
    Year published
    2006
    Metadata
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    Abstract
    Tumour necrosis factor (TNF)a is implicated in the relationship between obesity and insulin resistance/ type 2 diabetes. In an effort to understand this association better we (i) profiled gene expression patterns of TNF, TNFR1 and TNFR2 and (ii) investigated the effects of TNF on glucose uptake in isolated adipocytes and adipose tissue explants from omental and subcutaneous depots from lean, overweight and obese individuals. TNF expression correlated with expression of TNFR2, but not TNFR1, and TNF and TNFR2 expression increased in obesity. TNFR1 expression was higher in omental than in subcutaneous adipocytes. ...
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    Tumour necrosis factor (TNF)a is implicated in the relationship between obesity and insulin resistance/ type 2 diabetes. In an effort to understand this association better we (i) profiled gene expression patterns of TNF, TNFR1 and TNFR2 and (ii) investigated the effects of TNF on glucose uptake in isolated adipocytes and adipose tissue explants from omental and subcutaneous depots from lean, overweight and obese individuals. TNF expression correlated with expression of TNFR2, but not TNFR1, and TNF and TNFR2 expression increased in obesity. TNFR1 expression was higher in omental than in subcutaneous adipocytes. Expression levels of TNF or either receptor did not differ between adipocytes from individuals with central and peripheral obesity. TNF only suppressed glucose uptake in insulin-stimulated subcutaneous tissue and this suppression was only observed in tissue from lean subjects. These data support a relationship between the TNF system and body mass index (BMI), but not fat distribution, and suggest depot specificity of the TNF effect on glucose uptake. Furthermore, adipose tissue from obese subjects already appears insulin 'resistant' and this may be a result of the increased TNF levels.
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    Journal Title
    Diabetes and Vascular Disease Research
    Volume
    3
    Issue
    1
    DOI
    https://doi.org/10.3132/dvdr.2006.003
    Subject
    Cardiorespiratory Medicine and Haematology not elsewhere classified
    Clinical Sciences
    Pharmacology and Pharmaceutical Sciences
    Medical Physiology
    Publication URI
    http://hdl.handle.net/10072/27211
    Collection
    • Journal articles

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