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dc.contributor.authorS. McLennan, Ian
dc.contributor.authorW. Weible II, Michael
dc.contributor.authorA. Hendry, Ian
dc.contributor.authorKoishi, Kyoko
dc.date.accessioned2017-05-03T16:58:31Z
dc.date.available2017-05-03T16:58:31Z
dc.date.issued2005
dc.date.modified2009-12-09T07:39:41Z
dc.identifier.issn00283908
dc.identifier.doi10.1016/j.neuropharm.2004.10.005
dc.identifier.urihttp://hdl.handle.net/10072/27243
dc.description.abstractThe blood–brain barrier acts as an interface between the brain and body through a combination of restrictive mechanisms and transport processes. Substances essential for brain function pass through the barrier either by passive diffusion or by active transport. We report here that [125I]-transforming growth factor-β2 (TGF-β2) passes through the blood–brain barrier and blood–nerve barriers, after intravenous, intraperitoneal or intramuscular injections. The entry of the [125I]-TGF-β2 to the brain was rapid, saturable and inhibited by co-injection of unlabelled TGF-β2. In contrast, co-injection of unlabelled TGF-β2 increased the retention of [125I]-TGF-β2 in the blood. The [125I]-TGF-β2 transported into the brain was localised by autoradiography to the extracellular space, and was intact as judged by SDS-PAGE. The [125I]-TGF-β2 was widely distributed throughout the brain, with the highest concentrations in the hypothalamus and nerves and the lowest in the cerebral hemispheres. The [125I]-TGF-β2 had a half-life of 4 h in the brain. These results indicate that therapeutically relevant levels of TGF-β2 reach the brain after peripheral administration of TGF-β2.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherPergamon
dc.publisher.placeUK
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom274
dc.relation.ispartofpageto282
dc.relation.ispartofissue2
dc.relation.ispartofjournalNeuropharmacology
dc.relation.ispartofvolume48
dc.rights.retentionY
dc.subject.fieldofresearchNeurosciences not elsewhere classified
dc.subject.fieldofresearchNeurosciences
dc.subject.fieldofresearchPharmacology and Pharmaceutical Sciences
dc.subject.fieldofresearchPsychology
dc.subject.fieldofresearchcode110999
dc.subject.fieldofresearchcode1109
dc.subject.fieldofresearchcode1115
dc.subject.fieldofresearchcode1701
dc.titleTransport of transforming growth factor-β2 across the blood-brain barrier
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.date.issued2005
gro.hasfulltextNo Full Text
gro.griffith.authorWeible, Michael W.


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