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dc.contributor.authorArata, Akikoen_US
dc.contributor.authorArata, Satoruen_US
dc.contributor.authorBouchard, Maximeen_US
dc.contributor.authorBusslinger, Meinraden_US
dc.contributor.authorChen, Chih-Lien_US
dc.contributor.authorCheng, Lepingen_US
dc.contributor.authorGoulding, Martynen_US
dc.contributor.authorGray, Paulen_US
dc.contributor.authorKarunaratne, Asankaen_US
dc.contributor.authorLuo, Pingen_US
dc.contributor.authorMa, Qiufuen_US
dc.contributor.authorMizuguchi, Rumikoen_US
dc.contributor.authorOnimaru, Hiroshien_US
dc.contributor.authorQian, Yingen_US
dc.contributor.authorShirasawa, Senjien_US
dc.date.accessioned2017-04-04T20:58:45Z
dc.date.available2017-04-04T20:58:45Z
dc.date.issued2004en_US
dc.date.modified2009-12-10T08:48:24Z
dc.identifier.issn10976256en_US
dc.identifier.doi10.1038/nn1221en_AU
dc.identifier.urihttp://hdl.handle.net/10072/27295
dc.description.abstractGlutamatergic and GABAergic neurons mediate much of the excitatory and inhibitory neurotransmission, respectively, in the vertebrate nervous system. The process by which developing neurons select between these two cell fates is poorly understood. Here we show that the homeobox genes Tlx3 and Tlx1 determine excitatory over inhibitory cell fates in the mouse dorsal spinal cord. First, we found that Tlx3 was required for specification of, and expressed in, glutamatergic neurons. Both generic and region-specific glutamatergic markers, including VGLUT2 and the AMPA receptor Gria2, were absent in Tlx mutant dorsal horn. Second, spinal GABAergic markers were derepressed in Tlx mutants, including Pax2 that is necessary for GABAergic differentiation, Gad1/2 and Viaat that regulate GABA synthesis and transport, and the kainate receptors Grik2/3. Third, ectopic expression of Tlx3 was sufficient to suppress GABAergic differentiation and induce formation of glutamatergic neurons. Finally, excess GABA-mediated inhibition caused dysfunction of central respiratory circuits in Tlx3 mutant mice.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_AU
dc.languageEnglishen_US
dc.language.isoen_AU
dc.publisherNature Publishing Groupen_US
dc.publisher.placeUnited Statesen_US
dc.publisher.urihttp://www.nature.com/neuro/en_AU
dc.relation.ispartofpagefrom510en_US
dc.relation.ispartofpageto517en_US
dc.relation.ispartofissue5en_AU
dc.relation.ispartofjournalNature Neuroscienceen_US
dc.relation.ispartofvolume7en_US
dc.subject.fieldofresearchcode270210en_US
dc.titleTlx3 and Tlx1 are post-mitotic selector genes determining glutamatergic over GABAergic cell fatesen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.date.issued2004
gro.hasfulltextNo Full Text


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