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dc.contributor.authorC. Bulmer, Andrewen_US
dc.contributor.authorT. Blanchfield, Joanneen_US
dc.contributor.authorToth, Istvanen_US
dc.contributor.authorG. Fassett, Roberten_US
dc.contributor.authorS. Coombes, Jeffen_US
dc.date.accessioned2017-04-24T14:56:47Z
dc.date.available2017-04-24T14:56:47Z
dc.date.issued2008en_US
dc.date.modified2009-12-11T06:45:49Z
dc.identifier.issn00219150en_US
dc.identifier.doi10.1016/j.atherosclerosis.2007.11.022en_AU
dc.identifier.urihttp://hdl.handle.net/10072/27374
dc.description.abstractBilirubin is a potent antioxidant, however, uncertainty surrounds its physiological importance. Individuals with Gilbert's syndrome (GS) have increased circulating bilirubin and a reduced prevalence of cardiovascular disease (CVD). The aim of this study was to investigate mechanisms that may link bilirubin to protection from CVD seen in GS by examining markers of antioxidant and oxidative stress status and the susceptibility of serum to oxidation. Nine individuals with GS and twelve controls, matched for age, height and weight, were assessed for plasma antioxidant status, red blood cell antioxidant enzyme activities, plasma malondialdehyde, the susceptibility of serum to copper (Cu2+) induced oxidation and blood lipid profile. Individuals with GS had significantly elevated unconjugated bilirubin (GS: 26.0 ᠶ.4; control: 9.7 ᠳ.0 孯l/L; P < 0.001), increased trolox equivalent antioxidant capacity (GS: 1.59 ᠰ.07; control: 1.52 ᠰ.07 mmol/L trolox Equ; P = 0.035) and ferric reducing ability of plasma (GS: 1.09 ᠰ.16; control: 0.92 ᠰ.14 mmol/L Fe2+ Equ; P = 0.024). The lag phase of serum oxidation was significantly longer in the GS group (GS: 121.4 ᠱ0.5; control: 106.8 ᠱ4.6 min; P = 0.020) and was positively correlated with the bilirubin concentration (r = 0.451, P = 0.040). A trend toward elevated HDL:LDL ratio was observed in GS (GS 0.96 ᠰ.31; control: 0.73 ᠰ.21; P = 0.072). In summary, individuals with GS have an increased circulating antioxidant status and an improved resistance to serum oxidation which may partially explain their reduced prevalence of CVD.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_AU
dc.languageEnglishen_US
dc.language.isoen_AU
dc.publisherElsevier Ireland Ltden_US
dc.publisher.placeIrelanden_US
dc.publisher.urihttp://www.atherosclerosis-journal.com/homeen_AU
dc.relation.ispartofstudentpublicationNen_AU
dc.relation.ispartofpagefrom390en_US
dc.relation.ispartofpageto396en_US
dc.relation.ispartofissue2en_US
dc.relation.ispartofjournalAtherosclerosisen_US
dc.relation.ispartofvolume199en_US
dc.rights.retentionYen_AU
dc.subject.fieldofresearchcode320000en_US
dc.titleImproved resistance to serum oxidation in Gilbert's syndrome: A mechanism for cardiovascular protectionen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.date.issued2008
gro.hasfulltextNo Full Text


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