Show simple item record

dc.contributor.authorBulmer, A.en_US
dc.contributor.authorRied, K.en_US
dc.contributor.authorBlanchfield, J.en_US
dc.contributor.authorWagner, K.en_US
dc.date.accessioned2017-04-24T14:56:51Z
dc.date.available2017-04-24T14:56:51Z
dc.date.issued2008en_US
dc.date.modified2009-12-14T03:13:26Z
dc.identifier.issn13835742en_US
dc.identifier.doi10.1016/j.mrrev.2007.05.001en_AU
dc.identifier.urihttp://hdl.handle.net/10072/27411
dc.description.abstractBile pigments, including bilirubin and biliverdin, are endogenous compounds belonging to the porphyrin family of molecules. In the past, bile pigments and bilirubin in particular were thought of as useless by-products of heme catabolism that can be toxic if they accumulate. However, in the past 20 years, research probing the physiological relevance of bile pigments has been mounting, with evidence to suggest bile pigments possess significant antioxidant and anti-mutagenic properties. More specifically, bile pigments are potent peroxyl radical scavengers and inhibit the mutagenic effects of a number of classes of mutagens (polycyclic aromatic hydrocarbons, heterocyclic amines, oxidants). Coincidentally, persons with elevated circulating bilirubin concentrations have a reduced prevalence of cancer and cardio-vascular disease. Despite the encouraging in vitro anti-mutagenic effects of bile pigments, relatively little research has been conducted on their inhibitory capacity in bacterial and cultured cell assays of mutation, which might link the existing in vitro and in vivo observations. This is the first review to summarise the published data and it is our hope it will stimulate further research on these potentially preventative compounds.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_AU
dc.languageEnglishen_US
dc.language.isoen_AU
dc.publisherElsevier BVen_US
dc.publisher.placeNetherlandsen_US
dc.publisher.urihttp://www.elsevier.com/wps/find/journaldescription.cws_home/506097/description#descriptionen_AU
dc.relation.ispartofstudentpublicationNen_AU
dc.relation.ispartofpagefrom28en_US
dc.relation.ispartofpageto41en_US
dc.relation.ispartofissue1-2en_US
dc.relation.ispartofjournalMutation Research - Reviewsen_US
dc.relation.ispartofvolume658en_US
dc.rights.retentionYen_AU
dc.subject.fieldofresearchMedical and Health Sciences not elsewhere classifieden_US
dc.subject.fieldofresearchcode119999en_US
dc.titleThe anti-mutagenic properties of bile pigmentsen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.date.issued2008
gro.hasfulltextNo Full Text


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

  • Journal articles
    Contains articles published by Griffith authors in scholarly journals.

Show simple item record