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dc.contributor.authorNachamkin, Irvingen_US
dc.contributor.authorV. Shadomy, Seanen_US
dc.contributor.authorP. Moran, Anthonyen_US
dc.contributor.authorCox, Nancyen_US
dc.contributor.authorFitzgerald, Colletteen_US
dc.contributor.authorUng, Huongen_US
dc.contributor.authorT. Corcoran, Adrianen_US
dc.contributor.authorK. Iskander, Johnen_US
dc.contributor.authorB. Schonberger, Lawrenceen_US
dc.contributor.authorT. Chen, Roberten_US
dc.date.accessioned2017-04-24T09:04:06Z
dc.date.available2017-04-24T09:04:06Z
dc.date.issued2008en_US
dc.date.modified2009-12-14T07:53:39Z
dc.identifier.issn00221899en_US
dc.identifier.doi10.1086/589624en_AU
dc.identifier.urihttp://hdl.handle.net/10072/27448
dc.description.abstractBackground: Receipt of an A/NJ/1976/H1N1 "swine flu" vaccine in 1976, unlike receipt of influenza vaccines used in subsequent years, was strongly associated with the development of the neurologic disorder Guillain-Barr頳yndrome (GBS). Anti-ganglioside antibodies (e.g., anti-GM1) are associated with the development of GBS, and we hypothesized that the swine flu vaccine contained contaminating moieties (such as Campylobacter jejuni antigens that mimic human gangliosides or other vaccine components) that elicited an anti-GM1 antibody response in susceptible recipients. Methods: Surviving samples of monovalent and bivalent 1976 vaccine, comprising those from 3 manufacturers and 11 lot numbers, along with several contemporary vaccines were tested for hemagglutinin (HA) activity, the presence of Campylobacter DNA, and the ability to induce anti-Campylobacter and anti-GM1 antibodies after inoculation into C3H/HeN mice. Results: We found that, although C. jejuni was not detected in 1976 swine flu vaccines, these vaccines induced anti-GM1 antibodies in mice, as did vaccines from 1991-1992 and 2004-2005. Preliminary studies suggest that the influenza HA induces anti-GM1 antibodies. Conclusions: Influenza vaccines contain structures that can induce anti-GM1 antibodies after inoculation into mice. Further research into influenza vaccine components that elicit anti-ganglioside responses and the role played by these antibodies (if any) in vaccine-associated GBS is warranted.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_AU
dc.languageEnglishen_US
dc.language.isoen_AU
dc.publisherUniversity of Chicago Pressen_US
dc.publisher.placeUSAen_US
dc.publisher.urihttp://www.journals.uchicago.edu/toc/jid/currenten_AU
dc.relation.ispartofstudentpublicationNen_AU
dc.relation.ispartofpagefrom226en_US
dc.relation.ispartofpageto233en_US
dc.relation.ispartofissue2en_US
dc.relation.ispartofjournalJournal of Infectious Diseasesen_US
dc.relation.ispartofvolume198en_US
dc.rights.retentionYen_AU
dc.subject.fieldofresearchCellular Immunologyen_US
dc.subject.fieldofresearchBacteriologyen_US
dc.subject.fieldofresearchcode110704en_US
dc.subject.fieldofresearchcode060501en_US
dc.titleAnti-ganglioside antibody induction by swine (A/NJ/1976/H1N1) and other influenza vaccines: Insights into vaccine-associated Guillain-Barre syndromeen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.date.issued2008
gro.hasfulltextNo Full Text


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