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  • Dietary red palm oil reduces ischaemia–reperfusion injury in rats fed a hypercholesterolaemic diet

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    Author(s)
    Kruger, MJ
    Engelbrecht, AM
    Esterhuyse, J
    du Toit, E
    van Rooyen, J
    Griffith University Author(s)
    Du Toit, Eugene
    Year published
    2007
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    Abstract
    We have previously shown that dietary red palm oil (RPO) supplementation improves functional recovery in hearts subjected to ischaemia-reperfusion. However, little knowledge exists concerning the effects of RPO supplementation of a high-cholesterol diet on ischaemia-reperfusion injury. The signalling mechanisms responsible for RPO's effects in the presence of cholesterol also remain to be elucidated. Therefore, the aim of the present study was to examine the effects of RPO, given with a high-cholesterol diet, on mitogen-activated protein kinase (MAPK) phosphorylation and apoptosis. Long-Evans rats were fed a control diet, a ...
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    We have previously shown that dietary red palm oil (RPO) supplementation improves functional recovery in hearts subjected to ischaemia-reperfusion. However, little knowledge exists concerning the effects of RPO supplementation of a high-cholesterol diet on ischaemia-reperfusion injury. The signalling mechanisms responsible for RPO's effects in the presence of cholesterol also remain to be elucidated. Therefore, the aim of the present study was to examine the effects of RPO, given with a high-cholesterol diet, on mitogen-activated protein kinase (MAPK) phosphorylation and apoptosis. Long-Evans rats were fed a control diet, a control diet containing 2 % cholesterol, or a control diet containing 2 % cholesterol and 7 g RPO per kg (CRPO) for 5 weeks. Hearts were excised and mounted on an isolated working heart perfusion apparatus. Cardiac function was measured after which hearts were freeze-clamped and used to assess MAPK phosphorylation and to evaluate apoptosis. Cholesterol supplementation caused a poor aortic output (AO) recovery compared with the control group (35絠(sem 6粩 v. 55素(sem 2絩 %), but when RPO was added, the percentage AO increased significantly. The cholesterol group's poor AO was associated with a significant increase in p38-MAPK phosphorylation, whereas the CRPO-supplemented group showed as significant reduction in p38-MAPK phosphorylation when compared with the cholesterol-supplemented group. This significant reduction in p38-MAPK was also associated with reduced apoptosis as indicated by significant reductions in caspase-3 and poly(ADP-ribose) polymerase cleavage.
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    Journal Title
    British Journal of Nutrition
    Volume
    97
    Issue
    4
    Publisher URI
    http://journals.cambridge.org/action/displayJournal?jid=BJN
    DOI
    https://doi.org/10.1017/S0007114507658991
    Copyright Statement
    © 2007 The Authors. The attached file is reproduced here in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version.
    Subject
    Animal production
    Food sciences
    Cardiology (incl. cardiovascular diseases)
    Nutrition and dietetics
    Publication URI
    http://hdl.handle.net/10072/27449
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    • Journal articles

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