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dc.contributor.authorEsterhuyse, A.en_US
dc.contributor.authordu Toit, E.en_US
dc.contributor.authorBenadè, A.en_US
dc.contributor.authorvan Rooyen, J.en_US
dc.date.accessioned2017-05-03T15:31:41Z
dc.date.available2017-05-03T15:31:41Z
dc.date.issued2005en_US
dc.identifier.issn09523278en_US
dc.identifier.doi10.1016/j.plefa.2004.10.014en_US
dc.identifier.urihttp://hdl.handle.net/10072/27450
dc.description.abstractIt has been shown that dietary red palm oil (RPO) supplementation improved reperfusion function. However, no exact protective cellular mechanisms have been established. Our aim was to search for a possible cellular mechanism and a role for fatty acids. Rats were fed a standard rat chow, plus cholesterol and/or RPO-supplementation for 6 weeks. Functional recovery, myocardial phospholipid and cAMP/cGMP levels were determined in isolated rat hearts subjected to 25 min of normothermic total global ischaemia. Dietary RPO in the presence of cholesterol improved aortic output (AO) recovery (63.2ᳮ06%, P<0.05) vs. cholesterol only (36.5ᶮ2%). The improved functional recovery in hearts supplemented with RPO vs. control was preceded by an elevation in the cGMP levels early in ischaemia (RPO 132.9ᳶ.3% vs. control 42.7Ჴ.4%, P<0.05). Concurrently, cAMP levels decreased (RPO -8.3ᶮ9% vs. control 19.9ᷮ7%, P<0.05). Our data suggest that dietary RPO-supplementation improved reperfusion AO through mechanisms that may include activation of the NO-cGMP and inhibition of the cAMP pathway.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_US
dc.languageEnglishen_US
dc.language.isoen_US
dc.publisherChurchill Livingstoneen_US
dc.publisher.placeEdinburgh, Scotland.en_US
dc.publisher.urihttp://www.elsevier.com/wps/find/journaldescription.cws_home/623065/description#descriptionen_US
dc.relation.ispartofstudentpublicationNen_US
dc.relation.ispartofpagefrom153en_US
dc.relation.ispartofpageto161en_US
dc.relation.ispartofissue3en_US
dc.relation.ispartofjournalProstaglandins, Leukotrienes & Essential Fatty Acidsen_US
dc.relation.ispartofvolume72en_US
dc.rights.retentionYen_US
dc.subject.fieldofresearchCardiology (incl. Cardiovascular Diseases)en_US
dc.subject.fieldofresearchcode110201en_US
dc.titleDietary red palm oil improves reperfusion cardiac function in the isolated perfused rat heart of animals fed a high cholesterol dieten_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.date.issued2015-05-31T22:17:24Z
gro.hasfulltextNo Full Text


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