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dc.contributor.authorEsterhuyse, AJ
dc.contributor.authorDu Toit, EF
dc.contributor.authorBenadeè, AJS
dc.contributor.authorVan Rooyen, J
dc.date.accessioned2017-05-03T15:31:41Z
dc.date.available2017-05-03T15:31:41Z
dc.date.issued2005
dc.identifier.issn0952-3278
dc.identifier.doi10.1016/j.plefa.2004.10.014
dc.identifier.urihttp://hdl.handle.net/10072/27450
dc.description.abstractIt has been shown that dietary red palm oil (RPO) supplementation improved reperfusion function. However, no exact protective cellular mechanisms have been established. Our aim was to search for a possible cellular mechanism and a role for fatty acids. Rats were fed a standard rat chow, plus cholesterol and/or RPO-supplementation for 6 weeks. Functional recovery, myocardial phospholipid and cAMP/cGMP levels were determined in isolated rat hearts subjected to 25 min of normothermic total global ischaemia. Dietary RPO in the presence of cholesterol improved aortic output (AO) recovery (63.2ᳮ06%, P<0.05) vs. cholesterol only (36.5ᶮ2%). The improved functional recovery in hearts supplemented with RPO vs. control was preceded by an elevation in the cGMP levels early in ischaemia (RPO 132.9ᳶ.3% vs. control 42.7Ჴ.4%, P<0.05). Concurrently, cAMP levels decreased (RPO -8.3ᶮ9% vs. control 19.9ᷮ7%, P<0.05). Our data suggest that dietary RPO-supplementation improved reperfusion AO through mechanisms that may include activation of the NO-cGMP and inhibition of the cAMP pathway.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherChurchill Livingstone
dc.publisher.placeEdinburgh, Scotland.
dc.publisher.urihttp://www.elsevier.com/wps/find/journaldescription.cws_home/623065/description#description
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom153
dc.relation.ispartofpageto161
dc.relation.ispartofissue3
dc.relation.ispartofjournalProstaglandins, Leukotrienes & Essential Fatty Acids
dc.relation.ispartofvolume72
dc.rights.retentionY
dc.subject.fieldofresearchBiochemistry and cell biology
dc.subject.fieldofresearchCardiology (incl. cardiovascular diseases)
dc.subject.fieldofresearchClinical sciences
dc.subject.fieldofresearchNutrition and dietetics
dc.subject.fieldofresearchcode3101
dc.subject.fieldofresearchcode320101
dc.subject.fieldofresearchcode3202
dc.subject.fieldofresearchcode3210
dc.titleDietary red palm oil improves reperfusion cardiac function in the isolated perfused rat heart of animals fed a high cholesterol diet
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.date.issued2015-05-31T22:17:24Z
gro.hasfulltextNo Full Text
gro.griffith.authorDu Toit, Eugene


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