dc.contributor.author | Esterhuyse, AJ | |
dc.contributor.author | Du Toit, EF | |
dc.contributor.author | Benadeè, AJS | |
dc.contributor.author | Van Rooyen, J | |
dc.date.accessioned | 2017-05-03T15:31:41Z | |
dc.date.available | 2017-05-03T15:31:41Z | |
dc.date.issued | 2005 | |
dc.identifier.issn | 0952-3278 | |
dc.identifier.doi | 10.1016/j.plefa.2004.10.014 | |
dc.identifier.uri | http://hdl.handle.net/10072/27450 | |
dc.description.abstract | It has been shown that dietary red palm oil (RPO) supplementation improved reperfusion function. However, no exact protective cellular mechanisms have been established. Our aim was to search for a possible cellular mechanism and a role for fatty acids. Rats were fed a standard rat chow, plus cholesterol and/or RPO-supplementation for 6 weeks. Functional recovery, myocardial phospholipid and cAMP/cGMP levels were determined in isolated rat hearts subjected to 25 min of normothermic total global ischaemia. Dietary RPO in the presence of cholesterol improved aortic output (AO) recovery (63.2ᳮ06%, P<0.05) vs. cholesterol only (36.5ᶮ2%). The improved functional recovery in hearts supplemented with RPO vs. control was preceded by an elevation in the cGMP levels early in ischaemia (RPO 132.9ᳶ.3% vs. control 42.7Ჴ.4%, P<0.05). Concurrently, cAMP levels decreased (RPO -8.3ᶮ9% vs. control 19.9ᷮ7%, P<0.05). Our data suggest that dietary RPO-supplementation improved reperfusion AO through mechanisms that may include activation of the NO-cGMP and inhibition of the cAMP pathway. | |
dc.description.peerreviewed | Yes | |
dc.description.publicationstatus | Yes | |
dc.language | English | |
dc.language.iso | eng | |
dc.publisher | Churchill Livingstone | |
dc.publisher.place | Edinburgh, Scotland. | |
dc.publisher.uri | http://www.elsevier.com/wps/find/journaldescription.cws_home/623065/description#description | |
dc.relation.ispartofstudentpublication | N | |
dc.relation.ispartofpagefrom | 153 | |
dc.relation.ispartofpageto | 161 | |
dc.relation.ispartofissue | 3 | |
dc.relation.ispartofjournal | Prostaglandins, Leukotrienes & Essential Fatty Acids | |
dc.relation.ispartofvolume | 72 | |
dc.rights.retention | Y | |
dc.subject.fieldofresearch | Biochemistry and cell biology | |
dc.subject.fieldofresearch | Cardiology (incl. cardiovascular diseases) | |
dc.subject.fieldofresearch | Clinical sciences | |
dc.subject.fieldofresearch | Nutrition and dietetics | |
dc.subject.fieldofresearchcode | 3101 | |
dc.subject.fieldofresearchcode | 320101 | |
dc.subject.fieldofresearchcode | 3202 | |
dc.subject.fieldofresearchcode | 3210 | |
dc.title | Dietary red palm oil improves reperfusion cardiac function in the isolated perfused rat heart of animals fed a high cholesterol diet | |
dc.type | Journal article | |
dc.type.description | C1 - Articles | |
dc.type.code | C - Journal Articles | |
gro.date.issued | 2015-05-31T22:17:24Z | |
gro.hasfulltext | No Full Text | |
gro.griffith.author | Du Toit, Eugene | |