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dc.contributor.authorBrowne, HAK
dc.contributor.authorAdams, L
dc.contributor.authorSimonds, AK
dc.contributor.authorMorrell, MJ
dc.date.accessioned2017-05-03T13:56:56Z
dc.date.available2017-05-03T13:56:56Z
dc.date.issued2003
dc.date.modified2009-12-14T07:54:24Z
dc.identifier.issn0903-1936
dc.identifier.doi10.1183/09031936.03.00039002
dc.identifier.urihttp://hdl.handle.net/10072/27458
dc.description.abstractIn young people, a sleep-related reduction in the gain of the ventilatory chemoreflex feedback loop occurs; in the elderly, it has been reported that no sleeprelated reduction occurs. A relatively high loop gain could contribute to periodic breathing and central sleep apnoea in the elderly. This study tested the hypothesis that ageing is associated with a reduction in the magnitude of the sleep-related decrease in the hypercapnic ventilatory response (HCVR). The HCVR was measured using a steady state method, awake and asleep, in groups (n=10) of elderly (66-81 yrs) and young (23-35 yrs) nonapnoeics. Upper airway resistance was maintained close to wakefulness levels using continuous positive airway pressure (mean sleep-related increase in resistance: elderly 1.6ᱮ2 cmH2O?L?s-1, young 1.2ᰮ8 cmH2O?L?s-1). The sleep-related decrease in the HCVR was similar in the elderly and young groups (elderly: wake 0.14ᰮ06 and sleep 0.06ᰮ02 L?min-1?kPa and young, wake 0.19ᰮ07 and sleep 0.10ᰮ04 L?min-1?kPa). Ageing per se was shown not to change the magnitude of the sleep-related decrease in hypercapnic ventilatory response. The authors speculate that age-related changes in the hypercapnic ventilatory response are unlikely to contribute to the increased prevalence of central sleep apnoea in the elderly.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherEuropean Respiratory Society
dc.publisher.placeSwitzerland
dc.publisher.urihttp://www.erj.ersjournals.com/
dc.relation.ispartofpagefrom523
dc.relation.ispartofpageto529
dc.relation.ispartofissue3
dc.relation.ispartofjournalEuropean Respiratory Journal
dc.relation.ispartofvolume21
dc.subject.fieldofresearchBiomedical and clinical sciences
dc.subject.fieldofresearchcode32
dc.titleAgeing does not influence the sleep-related decrease in the hypercapnic ventilatory response
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.date.issued2003
gro.hasfulltextNo Full Text
gro.griffith.authorAdams, Lewis


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