dc.contributor.author | Browne, HAK | |
dc.contributor.author | Adams, L | |
dc.contributor.author | Simonds, AK | |
dc.contributor.author | Morrell, MJ | |
dc.date.accessioned | 2017-05-03T13:56:56Z | |
dc.date.available | 2017-05-03T13:56:56Z | |
dc.date.issued | 2003 | |
dc.date.modified | 2009-12-14T07:54:24Z | |
dc.identifier.issn | 0903-1936 | |
dc.identifier.doi | 10.1183/09031936.03.00039002 | |
dc.identifier.uri | http://hdl.handle.net/10072/27458 | |
dc.description.abstract | In young people, a sleep-related reduction in the gain of the ventilatory chemoreflex feedback loop occurs; in the elderly, it has been reported that no sleeprelated reduction occurs. A relatively high loop gain could contribute to periodic breathing and central sleep apnoea in the elderly. This study tested the hypothesis that ageing is associated with a reduction in the magnitude of the sleep-related decrease in the hypercapnic ventilatory response (HCVR). The HCVR was measured using a steady state method, awake and asleep, in groups (n=10) of elderly (66-81 yrs) and young (23-35 yrs) nonapnoeics. Upper airway resistance was maintained close to wakefulness levels using continuous positive airway pressure (mean sleep-related increase in resistance: elderly 1.6ᱮ2 cmH2O?L?s-1, young 1.2ᰮ8 cmH2O?L?s-1). The sleep-related decrease in the HCVR was similar in the elderly and young groups (elderly: wake 0.14ᰮ06 and sleep 0.06ᰮ02 L?min-1?kPa and young, wake 0.19ᰮ07 and sleep 0.10ᰮ04 L?min-1?kPa). Ageing per se was shown not to change the magnitude of the sleep-related decrease in hypercapnic ventilatory response. The authors speculate that age-related changes in the hypercapnic ventilatory response are unlikely to contribute to the increased prevalence of central sleep apnoea in the elderly. | |
dc.description.peerreviewed | Yes | |
dc.description.publicationstatus | Yes | |
dc.language | English | |
dc.language.iso | eng | |
dc.publisher | European Respiratory Society | |
dc.publisher.place | Switzerland | |
dc.publisher.uri | http://www.erj.ersjournals.com/ | |
dc.relation.ispartofpagefrom | 523 | |
dc.relation.ispartofpageto | 529 | |
dc.relation.ispartofissue | 3 | |
dc.relation.ispartofjournal | European Respiratory Journal | |
dc.relation.ispartofvolume | 21 | |
dc.subject.fieldofresearch | Biomedical and clinical sciences | |
dc.subject.fieldofresearchcode | 32 | |
dc.title | Ageing does not influence the sleep-related decrease in the hypercapnic ventilatory response | |
dc.type | Journal article | |
dc.type.description | C1 - Articles | |
dc.type.code | C - Journal Articles | |
gro.date.issued | 2003 | |
gro.hasfulltext | No Full Text | |
gro.griffith.author | Adams, Lewis | |