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dc.contributor.authorAdams, Lewisen_US
dc.contributor.authorBrowne, H.en_US
dc.contributor.authorMorrell, M.en_US
dc.contributor.authorSimonds, A.en_US
dc.date.accessioned2017-04-04T18:22:32Z
dc.date.available2017-04-04T18:22:32Z
dc.date.issued2003en_US
dc.date.modified2009-12-14T07:54:24Z
dc.identifier.issn09031936en_US
dc.identifier.doi10.1183/09031936.03.00039002en_AU
dc.identifier.urihttp://hdl.handle.net/10072/27458
dc.description.abstractIn young people, a sleep-related reduction in the gain of the ventilatory chemoreflex feedback loop occurs; in the elderly, it has been reported that no sleeprelated reduction occurs. A relatively high loop gain could contribute to periodic breathing and central sleep apnoea in the elderly. This study tested the hypothesis that ageing is associated with a reduction in the magnitude of the sleep-related decrease in the hypercapnic ventilatory response (HCVR). The HCVR was measured using a steady state method, awake and asleep, in groups (n=10) of elderly (66-81 yrs) and young (23-35 yrs) nonapnoeics. Upper airway resistance was maintained close to wakefulness levels using continuous positive airway pressure (mean sleep-related increase in resistance: elderly 1.6ᱮ2 cmH2O?L?s-1, young 1.2ᰮ8 cmH2O?L?s-1). The sleep-related decrease in the HCVR was similar in the elderly and young groups (elderly: wake 0.14ᰮ06 and sleep 0.06ᰮ02 L?min-1?kPa and young, wake 0.19ᰮ07 and sleep 0.10ᰮ04 L?min-1?kPa). Ageing per se was shown not to change the magnitude of the sleep-related decrease in hypercapnic ventilatory response. The authors speculate that age-related changes in the hypercapnic ventilatory response are unlikely to contribute to the increased prevalence of central sleep apnoea in the elderly.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_AU
dc.languageEnglishen_US
dc.language.isoen_AU
dc.publisherEuropean Respiratory Societyen_US
dc.publisher.placeSwitzerlanden_US
dc.publisher.urihttp://www.erj.ersjournals.com/en_AU
dc.relation.ispartofpagefrom523en_US
dc.relation.ispartofpageto529en_US
dc.relation.ispartofissue3en_AU
dc.relation.ispartofjournalEuropean Respiratory Journalen_US
dc.relation.ispartofvolume21en_US
dc.subject.fieldofresearchcode320603en_US
dc.subject.fieldofresearchcode321007en_US
dc.subject.fieldofresearchcode321027en_US
dc.titleAgeing does not influence the sleep-related decrease in the hypercapnic ventilatory responseen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.date.issued2003
gro.hasfulltextNo Full Text


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