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dc.contributor.authorEaston, DF
dc.contributor.authorPooley, KA
dc.contributor.authorDunning, AM
dc.contributor.authorPharoah, PDP
dc.contributor.authorThompson, D
dc.contributor.authorBallinger, DG
dc.contributor.authorStruewing, JP
dc.contributor.authorMorrison, J
dc.contributor.authorField, H
dc.contributor.authorLuben, R
dc.contributor.authorWareham, N
dc.contributor.authorAhmed, S
dc.contributor.authorHealey, CS
dc.contributor.authorBowman, R
dc.contributor.authorMeyer, KB
dc.contributor.authorHaiman, CA
dc.contributor.authorKolonel, LK
dc.contributor.authorHenderson, BE
dc.contributor.authorLe Marchand, L
dc.contributor.authorBrennan, P
dc.contributor.authorSangrajrang, S
dc.contributor.authorGaborieau, V
dc.contributor.authorOdefrey, F
dc.contributor.authorShen, CY
dc.contributor.authorWu, PE
dc.contributor.authorWang, HC
dc.contributor.authorEccles, D
dc.contributor.authorEvans, DG
dc.contributor.authorPeto, J
dc.contributor.authorFletcher, O
dc.contributor.authorJohnson, N
dc.contributor.authorSeal, S
dc.contributor.authorStratton, MR
dc.contributor.authorRahman, N
dc.contributor.authorChenevix-Trench, G
dc.contributor.authorBojesen, SE
dc.contributor.authorNordestgaard, BG
dc.contributor.authorAxelsson, CK
dc.contributor.authorGarcia-Closas, M
dc.contributor.authorBrinton, L
dc.contributor.authorChanock, S
dc.contributor.authorLissowska, J
dc.contributor.authorPeplonska, B
dc.contributor.authorNevanlinna, H
dc.contributor.authorFagerholm, R
dc.contributor.authorEerola, H
dc.contributor.authorKang, D
dc.contributor.authorYoo, KY
dc.contributor.authorNoh, DY
dc.contributor.authorAhn, SH
dc.contributor.authorHunter, DJ
dc.contributor.authorHankinson, SE
dc.contributor.authorCox, DG
dc.contributor.authorHall, P
dc.contributor.authorWedren, S
dc.contributor.authorLiu, J
dc.contributor.authorLow, YL
dc.contributor.authorBogdanova, N
dc.contributor.authorSchürmann, P
dc.contributor.authorDörk, T
dc.contributor.authorTollenaar, RAEM
dc.contributor.authorJacobi, CE
dc.contributor.authorDevilee, P
dc.contributor.authorKlijn, JGM
dc.contributor.authorSigurdson, AJ
dc.contributor.authorDoody, MM
dc.contributor.authorAlexander, BH
dc.contributor.authorZhang, J
dc.contributor.authorCox, A
dc.contributor.authorBrock, IW
dc.contributor.authorMacPherson, G
dc.contributor.authorReed, MWR
dc.contributor.authorCouch, FJ
dc.contributor.authorGoode, EL
dc.contributor.authorOlson, JE
dc.contributor.authorMeijers-Heijboer, H
dc.contributor.authorVan Den Ouweland, A
dc.contributor.authorUitterlinden, A
dc.contributor.authorRivadeneira, F
dc.contributor.authorMilne, RL
dc.contributor.authorRibas, G
dc.contributor.authorGonzalez-Neira, A
dc.contributor.authorBenitez, J
dc.contributor.authorHopper, JL
dc.contributor.authorMcCredie, M
dc.contributor.authorSouthey, M
dc.contributor.authorGiles, G
dc.contributor.authorSchroen, C
dc.contributor.authorJustenhoven, C
dc.contributor.authorBrauch, H
dc.contributor.authorHamann, U
dc.contributor.authorKo, YD
dc.contributor.authorSpurdle, AB
dc.contributor.authorBeesley, J
dc.contributor.authorChen, X
dc.contributor.authorMannermaa, A
dc.contributor.authorKosma, VM
dc.contributor.authorKataja, V
dc.contributor.authorHartikainen, J
dc.contributor.authorDay, NE
dc.date.accessioned2018-07-31T05:07:03Z
dc.date.available2018-07-31T05:07:03Z
dc.date.issued2007
dc.identifier.issn0028-0836
dc.identifier.doi10.1038/nature05887
dc.identifier.urihttp://hdl.handle.net/10072/27478
dc.description.abstractBreast cancer exhibits familial aggregation, consistent with variation in genetic susceptibility to the disease. Known susceptibility genes account for less than 25% of the familial risk of breast cancer, and the residual genetic variance is likely to be due to variants conferring more moderate risks. To identify further susceptibility alleles, we conducted a two-stage genome-wide association study in 4,398 breast cancer cases and 4,316 controls, followed by a third stage in which 30 single nucleotide polymorphisms (SNPs) were tested for confirmation in 21,860 cases and 22,578 controls from 22 studies. We used 227,876 SNPs that were estimated to correlate with 77% of known common SNPs in Europeans at r2.0.5. SNPs in five novel independent loci exhibited strong and consistent evidence of association with breast cancer (P,1027). Four of these contain plausible causative genes (FGFR2, TNRC9, MAP3K1 and LSP1). At the second stage, 1,792 SNPs were significant at the P,0.05 level compared with an estimated 1,343 that would be expected by chance, indicating that many additional common susceptibility alleles may be identifiable by this approach.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherNature Publishing Group
dc.publisher.placeUnited Kingdom
dc.publisher.urihttp://www.nature.com/nature/index.html
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom1087
dc.relation.ispartofpageto1095
dc.relation.ispartofjournalNature
dc.relation.ispartofvolume447
dc.rights.retentionY
dc.subject.fieldofresearchGene Expression (incl. Microarray and other genome-wide approaches)
dc.subject.fieldofresearchcode060405
dc.titleGenome-wide association study identifies novel breast cancer susceptibility loci
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dc.description.versionAccepted Manuscript (AM)
gro.rights.copyright© 2007 Nature Publishing Group. This is the author-manuscript version of this paper. Reproduced in accordance with the copyright policy of the publisher. Please refer to the journal website for access to the definitive, published version.
gro.date.issued2014-10-10T01:56:25Z
gro.hasfulltextFull Text
gro.griffith.authorFleming, Jean S.


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