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  • Proposed mechanisms for red palm oil induced cardioprotection in a model of hyperlipidaemia in the rat

    Author(s)
    Esterhuyse, JS
    van Rooyen, J
    Strijdom, H
    Bester, D
    du Toit, EF
    Griffith University Author(s)
    Du Toit, Eugene
    Year published
    2006
    Metadata
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    Abstract
    High-cholesterol diets alter myocardial and vascular NO-cGMP signaling and have been implicated in ischaemic/reperfusion injury. We investigated the effects of dietary red palm oil (RPO) containing fatty acids, carotonoids, tocopherols and tocotrienols on myocardial ischaemic tolerance and NO-cGMP pathway function in the rat. Wistar rats were fed a standard rat chowᒐO, or a standard rat chow+cholesterolᒐO diet. Myocardial mechanical function and NO-cGMP signaling pathway intermediates were determined before, during and after 25 min ischaemia. RPO-supplementation improved aortic output recovery and increased myocardial ischaemic ...
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    High-cholesterol diets alter myocardial and vascular NO-cGMP signaling and have been implicated in ischaemic/reperfusion injury. We investigated the effects of dietary red palm oil (RPO) containing fatty acids, carotonoids, tocopherols and tocotrienols on myocardial ischaemic tolerance and NO-cGMP pathway function in the rat. Wistar rats were fed a standard rat chowᒐO, or a standard rat chow+cholesterolᒐO diet. Myocardial mechanical function and NO-cGMP signaling pathway intermediates were determined before, during and after 25 min ischaemia. RPO-supplementation improved aortic output recovery and increased myocardial ischaemic cGMP concentrations. Simulated ischaemia (hypoxia) increased cardiomyocyte nitric oxide levels in the two RPO supplemented groups, but not in control non-supplemented groups. RPO supplementation also increased hypoxic nitric oxide levels in the control diet fed, but not the cholesterol fed rats. These data suggest that dietary RPO may improve myocardial ischaemic tolerance by increasing bioavailability of NO and improving NO-cGMP signaling in the heart.
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    Journal Title
    Prostaglandins, Leukotrienes & Essential Fatty Acids
    Volume
    75
    Issue
    6
    Publisher URI
    http://www.sciencedirect.com/science/journal/09523278
    DOI
    https://doi.org/10.1016/j.plefa.2006.07.001
    Subject
    Biochemistry and cell biology
    Cardiology (incl. cardiovascular diseases)
    Clinical sciences
    Nutrition and dietetics
    Publication URI
    http://hdl.handle.net/10072/27479
    Collection
    • Journal articles

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