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dc.contributor.authorS. Esterhuyse, Johanen_US
dc.contributor.authorvan Rooyen, Jacquesen_US
dc.contributor.authorStrijdom, Hansen_US
dc.contributor.authorBester, Dirken_US
dc.contributor.authorF. du Toit, Eugeneen_US
dc.date.accessioned2017-04-24T13:06:03Z
dc.date.available2017-04-24T13:06:03Z
dc.date.issued2006en_US
dc.identifier.issn09523278en_US
dc.identifier.doi10.1016/j.plefa.2006.07.001en_US
dc.identifier.urihttp://hdl.handle.net/10072/27479
dc.description.abstractHigh-cholesterol diets alter myocardial and vascular NO-cGMP signaling and have been implicated in ischaemic/reperfusion injury. We investigated the effects of dietary red palm oil (RPO) containing fatty acids, carotonoids, tocopherols and tocotrienols on myocardial ischaemic tolerance and NO-cGMP pathway function in the rat. Wistar rats were fed a standard rat chowᒐO, or a standard rat chow+cholesterolᒐO diet. Myocardial mechanical function and NO-cGMP signaling pathway intermediates were determined before, during and after 25 min ischaemia. RPO-supplementation improved aortic output recovery and increased myocardial ischaemic cGMP concentrations. Simulated ischaemia (hypoxia) increased cardiomyocyte nitric oxide levels in the two RPO supplemented groups, but not in control non-supplemented groups. RPO supplementation also increased hypoxic nitric oxide levels in the control diet fed, but not the cholesterol fed rats. These data suggest that dietary RPO may improve myocardial ischaemic tolerance by increasing bioavailability of NO and improving NO-cGMP signaling in the heart.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_US
dc.languageEnglishen_US
dc.language.isoen_US
dc.publisherChurchill Livingstoneen_US
dc.publisher.placeEdinburgh, Scotlanden_US
dc.publisher.urihttp://www.sciencedirect.com/science/journal/09523278en_US
dc.relation.ispartofstudentpublicationNen_US
dc.relation.ispartofpagefrom375en_US
dc.relation.ispartofpageto384en_US
dc.relation.ispartofissue6en_US
dc.relation.ispartofjournalProstaglandins, Leukotrienes & Essential Fatty Acidsen_US
dc.relation.ispartofvolume75en_US
dc.rights.retentionYen_US
dc.subject.fieldofresearchCardiology (incl. Cardiovascular Diseases)en_US
dc.subject.fieldofresearchcode110201en_US
dc.titleProposed mechanisms for red palm oil induced cardioprotection in a model of hyperlipidaemia in the raten_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.date.issued2015-05-31T22:22:00Z
gro.hasfulltextNo Full Text


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