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dc.contributor.authorN. Peart, Jasonen_US
dc.contributor.authorR. Gross, Ericen_US
dc.contributor.authorJ. Gross, Garretten_US
dc.date.accessioned2017-05-03T13:03:38Z
dc.date.available2017-05-03T13:03:38Z
dc.date.issued2004en_US
dc.date.modified2009-12-16T07:11:22Z
dc.identifier.issn01602446en_US
dc.identifier.urihttp://hdl.handle.net/10072/27630
dc.description.abstractThe involvement of opioid receptor activation during ischemia-reperfusion is somewhat controversial. While it is generally accepted that activation of the 8-opioid receptor (DOR) is cardioprotective, and may indeed be an important mediator of ischemic preconditioning, the role of the K-opioid receptor (KOR) is less well understood. To this end, we examined three different KOR agonists and their effects upon infarct size and arrhythmia development. Male Sprague-Dawley rats were subjected to 30 minutes of occlusion followed by 90 minutes of reperfusion. Opioid receptor agonists were administered 10 minutes before the onset of ischemia, while the opioid antagonists were given 20 minutes before occlusion. Untreated rats exhibited an infarct size (IS/AAR%) of 52.4 ' 2.7%. Pretreatment with the DOR agonist, BW373U86, limited infarct development to 37.2 ' 1.8%, which was reversed by the selective DOR antagonist, BNTX. All three KOR agonists studied, U50,488, ICI 204,448, and BRL 52537 significantly reduced infarct size to levels comparable to that of BW373U86. The infarct-sparing effects of U50,488 and ICI 204,448 were abolished by the selective KOR antagonist, nor-BNI. Nor-BNI failed to inhibit the cardioprotective effects of BRL 52537. Furthermore, U50,488 and BRL 52537, but not ICI 204,448, significantly reduced the incidence of arrhythmias. These effects were not blocked by nor-BNI. These data demonstrate that KOR activation provides a similar degree of infarct size reduction as DOR activation. KOR agonists also reduced arrhythmogenesis; however, these responses appear to be independent of KOR activation.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_AU
dc.languageEnglishen_US
dc.language.isoen_AU
dc.publisherLippincott Williams & Wilkinsen_US
dc.publisher.placeUnited Statesen_US
dc.publisher.urihttp://journals.lww.com/cardiovascularpharm/Fulltext/2004/03000/Effect_of_Exogenous_Kappa_Opioid_Receptor.12.aspxen_US
dc.relation.ispartofpagefrom410en_US
dc.relation.ispartofpageto415en_US
dc.relation.ispartofissue3en_US
dc.relation.ispartofjournalJournal of Cardiovascular Pharmacologyen_US
dc.relation.ispartofvolume43en_US
dc.subject.fieldofresearchcode320503en_US
dc.titleEffect of exogenous kappa-opioid receptor activation in rat model of myocardial infarction.en_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.date.issued2004
gro.hasfulltextNo Full Text


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