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dc.contributor.authorPetcu, EB
dc.contributor.authorDunoiu, C
dc.contributor.authorIoana, M
dc.contributor.authorPirici, D
dc.contributor.authorMogoantǎ, L
dc.contributor.authorPopa-Wagner, A
dc.date.accessioned2017-05-03T15:15:31Z
dc.date.available2017-05-03T15:15:31Z
dc.date.issued2007
dc.date.modified2009-12-16T07:12:32Z
dc.identifier.issn1220-0522
dc.identifier.urihttp://hdl.handle.net/10072/27648
dc.description.abstractKindled seizures are widely used to model epileptogenesis, but the molecular mechanisms underlying the attainment of kindling status are largely unknown. Recently we showed that achievement of kindling status in the Sprague-Dawley rat is associated with a critical developmental interval of 25 ± 1 days; the identification of this long, well-defined developmental interval for inducing kindling status makes possible a dissection of the cellular and genetic events underlying this phenomenon and its relationship to normal and pathological brain function. Now we report the identification, by proteomics, of a modified variant of the Rieske iron-sulfur protein, a component of the mitochondrial cytochrome bc1 complex, whose isoelectric point is shifted toward more alkaline values in the hippocampus of kindled rats. By immunohistochemistry the Rieske protein is well-expressed in the hippocampus except in the CA1 subfield, a region of selective vulnerability to seizures in humans and animal models. We also noted an asymmetric, selective expression of the Rieske protein in the subgranular neurons of the dorsal dentate gyrus, a region implicated in neurogenesis. Abnormal changes in Rieske protein immunoreactivity also were found in sections obtained from human epileptic patients. These results suggest that the Rieske protein may play a role in the response of neurons to seizure activity and could give important new insights into the molecular pathogenesis of epilepsy.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherEditura Academiei Romane
dc.publisher.placeRomania
dc.publisher.urihttp://www.ear.ro/
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom17
dc.relation.ispartofpageto24
dc.relation.ispartofissue1
dc.relation.ispartofjournalRomanian Journal of Morphology and Embryology
dc.relation.ispartofvolume48
dc.rights.retentionY
dc.subject.fieldofresearchcode320702
dc.titleModified variant of the Rieske iron-sulfur protein in the hippocampus of kindled rats and human epileptic patients
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.facultyGriffith Health, School of Medicine
gro.date.issued2007
gro.hasfulltextNo Full Text
gro.griffith.authorPetcu, Eugen B.
gro.griffith.authorPopa-Wagner, Aurel


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