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dc.contributor.authorDunroy, HMA
dc.contributor.authorAdams, L
dc.contributor.authorCorfield, DR
dc.contributor.authorMorrell, MJ
dc.date.accessioned2017-05-03T13:56:56Z
dc.date.available2017-05-03T13:56:56Z
dc.date.issued2003
dc.date.modified2009-12-17T22:31:05Z
dc.identifier.issn1569-9048
dc.identifier.doi10.1016/S1569-9048(03)00080-6
dc.identifier.urihttp://hdl.handle.net/10072/27695
dc.description.abstractSome patients with lung disease retain CO2, while others with similar lung function do not. This could be explained if CO2 retainers had a pre-existing low hypercapnic ventilatory response (HCVR) and, from this, a tendency to retain CO2. To test if such a phenomenon exists in healthy people, we determined the change in end-tidal PCO2 (?PETCO2) produced by the addition of a dead-space (DS), during wakefulness and sleep, and related this to the HCVR measured awake. The group mean (n=14) HCVR slope was 2.2ᱮ1 (S.D.) L min-1 mmHg-1. The ?PETCO2 with the application of DS was 1.6ᱮ6 mmHg awake and 2.6Ხ2 mmHg asleep. During wakefulness the ?PETCO2 with DS did not correlate with the HCVR slope. However, during sleep, four subjects had a marked increase in the ?PETCO2 (3.7, 4.3, 6.2, 8.0 mmHg) and a relatively low HCVR (slope 1.5, 1.7, 1.5, 1.7 L min-1 mmHg-1, respectively). We speculate that such individuals, should they develop lung disease, may be predisposed to retain CO2.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier
dc.publisher.placeNetherlands
dc.publisher.urihttp://www.elsevier.com/locate/resphysiol
dc.relation.ispartofpagefrom179
dc.relation.ispartofpageto186
dc.relation.ispartofissue2-3
dc.relation.ispartofjournalRespiration Physiology & Neurobiology
dc.relation.ispartofvolume136
dc.subject.fieldofresearchCardiovascular medicine and haematology
dc.subject.fieldofresearchNeurosciences
dc.subject.fieldofresearchMedical physiology
dc.subject.fieldofresearchcode3201
dc.subject.fieldofresearchcode3209
dc.subject.fieldofresearchcode3208
dc.titleCO2 retention in lung disease; could there be a pre-existing difference in respiratory physiology
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.date.issued2003
gro.hasfulltextNo Full Text
gro.griffith.authorAdams, Lewis


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