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dc.contributor.authorM.A. Dunroy, Helenen_US
dc.contributor.authorAdams, Lewisen_US
dc.contributor.authorR. Corfield, Douglasen_US
dc.contributor.authorJ. Morrell, Maryen_US
dc.date.accessioned2017-05-03T13:56:56Z
dc.date.available2017-05-03T13:56:56Z
dc.date.issued2003en_US
dc.date.modified2009-12-17T22:31:05Z
dc.identifier.issn15699048en_US
dc.identifier.doi10.1016/S1569-9048(03)00080-6en_AU
dc.identifier.urihttp://hdl.handle.net/10072/27695
dc.description.abstractSome patients with lung disease retain CO2, while others with similar lung function do not. This could be explained if CO2 retainers had a pre-existing low hypercapnic ventilatory response (HCVR) and, from this, a tendency to retain CO2. To test if such a phenomenon exists in healthy people, we determined the change in end-tidal PCO2 (?PETCO2) produced by the addition of a dead-space (DS), during wakefulness and sleep, and related this to the HCVR measured awake. The group mean (n=14) HCVR slope was 2.2ᱮ1 (S.D.) L min-1 mmHg-1. The ?PETCO2 with the application of DS was 1.6ᱮ6 mmHg awake and 2.6Ხ2 mmHg asleep. During wakefulness the ?PETCO2 with DS did not correlate with the HCVR slope. However, during sleep, four subjects had a marked increase in the ?PETCO2 (3.7, 4.3, 6.2, 8.0 mmHg) and a relatively low HCVR (slope 1.5, 1.7, 1.5, 1.7 L min-1 mmHg-1, respectively). We speculate that such individuals, should they develop lung disease, may be predisposed to retain CO2.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_AU
dc.languageEnglishen_US
dc.language.isoen_AU
dc.publisherElsevier BVen_US
dc.publisher.placeNetherlandsen_US
dc.publisher.urihttp://www.elsevier.com/locate/resphysiolen_AU
dc.relation.ispartofpagefrom179en_US
dc.relation.ispartofpageto186en_US
dc.relation.ispartofissue2-3en_US
dc.relation.ispartofjournalRespiration Physiology & Neurobiologyen_US
dc.relation.ispartofvolume136en_US
dc.subject.fieldofresearchcode320603en_US
dc.titleCO2 retention in lung disease; could there be a pre-existing difference in respiratory physiologyen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.date.issued2003
gro.hasfulltextNo Full Text


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