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dc.contributor.authorBester, Dirk Jacobusen_US
dc.contributor.authorvan Rooyen, Jacquesen_US
dc.contributor.authorEF, Du Toiten_US
dc.contributor.authorEsterhuyse, A.en_US
dc.date.accessioned2017-05-03T16:59:32Z
dc.date.available2017-05-03T16:59:32Z
dc.date.issued2006en_US
dc.identifier.issn10115528en_US
dc.identifier.urihttp://hdl.handle.net/10072/27784
dc.description.abstractIt is a well known fact that the modern diet contains either excess polyunsaturated fats or saturated fats, and rarely a balanced fat content. In recent research it was found that high concentrations of PUFAs in the diet may be detrimental to cardiovascular health by increasing oxidative stress. Previous studies showed that red palm oil (RPO) provided effective protection against ischaemia/reperfusion injury. In this study we developed an oxidative risk induced diet (ORD), which is rich in PUFAs and low in SFAs, and a high saturated fat diet (HFD), which is rich in SFAs and low in PUFAs. These diets were either supplemented with RPO (experimental groups) or not supplemented (control). Our aim was to investigate whether RPO could offer protection against ischaemia/reperfusion injury in these diets. Our results showed that RPO was able to protect against ischaemia/reperfusion injury in both an ORD and a HFD as indicated by an increased aortic output recovery (ORD+RPO: 83.63 ᠱ.76 % versus 61.40 ᠳ.76 %; HFD+RPO: 66.17 ᠲ.85 % versus 50.00 ᠱ.64 %, P<0.05). This increase in reperfusion function was accompanied by an increase in cGMP concentrations during ischaemia in both RPO supplemented groups, when compared to the unsupplemented groups (195.40 ᠱ8.26% versus 90.31 ᠱ2.78 % for the ORD groups and 132.98 ᠱ2.41 % versus 50.09 ᠱ0.42 % for the HFD groups, P<0.05). These results suggest that the NO-cGMP pathway may be stimulated by RPO during oxidative stress. This in turn would lead to elevation of cGMP during reperfusion, which is associated with protection.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_US
dc.languageEnglishen_US
dc.language.isoen_US
dc.publisherSociety of Medical Laboratory Technologists of South Africaen_US
dc.publisher.placeSouth Africaen_US
dc.publisher.urihttp://www.smltsa.org.za/journal/index.htmen_US
dc.relation.ispartofstudentpublicationNen_US
dc.relation.ispartofpagefrom3en_US
dc.relation.ispartofpageto6en_US
dc.relation.ispartofissue1en_US
dc.relation.ispartofjournalMedical technology SAen_US
dc.relation.ispartofvolume21en_US
dc.rights.retentionYen_US
dc.subject.fieldofresearchCardiology (incl. Cardiovascular Diseases)en_US
dc.subject.fieldofresearchcode110201en_US
dc.titleRed palm oil protects against the consequences of oxidative stress when supplemented with dislipidaemic diets.en_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.date.issued2015-05-25T05:49:00Z
gro.hasfulltextNo Full Text


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