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  • Antimalarial activity of sera from subjects taking HIV protease inhibitors

    Author(s)
    Redmond, Andrew M
    Skinner-Adams, Tina
    Andrews, Katherine T
    Gardiner, Donald L
    Ray, John
    Kelly, Mark
    McCarthy, James S
    Griffith University Author(s)
    Andrews, Katherine T.
    Skinner-Adams, Tina
    Year published
    2007
    Metadata
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    Abstract
    Synergy between HIV and malaria is being increasingly recognized. We examined the antimalarial activity of sera from subjects receiving chloroquine, no drugs or HAART. Sera from subjects taking ritonavir-boosted saquinavir or lopinavir significantly inhibited parasite growth (median of 55 and 69% inhibition, respectively). These results indicate that patients on protease inhibitors may be afforded some protection from malaria. The clinical relevance of these observations will require confirmation in controlled studies in malaria-endemic regions.Synergy between HIV and malaria is being increasingly recognized. We examined the antimalarial activity of sera from subjects receiving chloroquine, no drugs or HAART. Sera from subjects taking ritonavir-boosted saquinavir or lopinavir significantly inhibited parasite growth (median of 55 and 69% inhibition, respectively). These results indicate that patients on protease inhibitors may be afforded some protection from malaria. The clinical relevance of these observations will require confirmation in controlled studies in malaria-endemic regions.
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    Journal Title
    AIDS
    Volume
    21
    Issue
    6
    Publisher URI
    https://journals.lww.com/aidsonline/Fulltext/2007/03300/Antimalarial_activity_of_sera_from_subjects_taking.16.aspx
    DOI
    https://doi.org/10.1097/QAD.0b013e328031f41a
    Subject
    Biological sciences
    Biomedical and clinical sciences
    Psychology
    Publication URI
    http://hdl.handle.net/10072/27809
    Collection
    • Journal articles

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