Antimalarial activity of sera from subjects taking HIV protease inhibitors
Author(s)
Redmond, Andrew M
Skinner-Adams, Tina
Andrews, Katherine T
Gardiner, Donald L
Ray, John
Kelly, Mark
McCarthy, James S
Year published
2007
Metadata
Show full item recordAbstract
Synergy between HIV and malaria is being increasingly recognized. We examined the antimalarial activity of sera from subjects receiving chloroquine, no drugs or HAART. Sera from subjects taking ritonavir-boosted saquinavir or lopinavir significantly inhibited parasite growth (median of 55 and 69% inhibition, respectively). These results indicate that patients on protease inhibitors may be afforded some protection from malaria. The clinical relevance of these observations will require confirmation in controlled studies in malaria-endemic regions.Synergy between HIV and malaria is being increasingly recognized. We examined the antimalarial activity of sera from subjects receiving chloroquine, no drugs or HAART. Sera from subjects taking ritonavir-boosted saquinavir or lopinavir significantly inhibited parasite growth (median of 55 and 69% inhibition, respectively). These results indicate that patients on protease inhibitors may be afforded some protection from malaria. The clinical relevance of these observations will require confirmation in controlled studies in malaria-endemic regions.
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Journal Title
AIDS
Volume
21
Issue
6
Publisher URI
Subject
Biological sciences
Biomedical and clinical sciences
Psychology
Health sciences