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  • Synergistic Interactions of the Antiretroviral Protease Inhibitors Saquinavir and Ritonavir with Chloroquine and Mefloquine against Plasmodium falciparum In Vitro

    Author(s)
    Skinner-Adams, TS
    Andrews, KT
    Melville, L
    McCarthy, J
    Gardiner, DL
    Griffith University Author(s)
    Andrews, Katherine T.
    Skinner-Adams, Tina
    Year published
    2007
    Metadata
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    Abstract
    The antimalarial activity of several antiretroviral protease inhibitor combinations was investigated. Data demonstrate that ritonavir and saquinavir behave synergistically with chloroquine and mefloquine. These data, and interactions with pepstatin-A, E-64, and bestatin, suggest that human immunodeficiency virus protease inhibitors do not target digestive-vacuole plasmepsins.The antimalarial activity of several antiretroviral protease inhibitor combinations was investigated. Data demonstrate that ritonavir and saquinavir behave synergistically with chloroquine and mefloquine. These data, and interactions with pepstatin-A, E-64, and bestatin, suggest that human immunodeficiency virus protease inhibitors do not target digestive-vacuole plasmepsins.
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    Journal Title
    Antimicrobial agents and Chemotherapy
    Volume
    51
    Issue
    2
    Publisher URI
    http://www.asm.org/
    DOI
    https://doi.org/10.1128/AAC.00840-06
    Subject
    Microbiology
    Medical microbiology
    Pharmacology and pharmaceutical sciences
    Publication URI
    http://hdl.handle.net/10072/27820
    Collection
    • Journal articles

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