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  • Evaluation of the role of the endocytic receptor L-SIGN for cytoadhesion of Plasmodium falciparum-infected erythrocytes

    Author(s)
    Viebig, NK
    Andrews, KT
    van Kooyk, Y
    Lanzer, M
    Knolle, PA
    Griffith University Author(s)
    Andrews, Katherine T.
    Year published
    2005
    Metadata
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    Abstract
    Hepatic cell populations play an important role during the malaria life cycle. L-SIGN, a homologue of DC-SIGN, mediating leukocyte and pathogen binding, is selectively expressed on liver endothelial cells. Here, we present evidence that L-SIGN acts as an endocytic cell surface receptor. However, P. falciparum-infected erythrocytes did not cytoadhere to L-SIGN. Thus, L-SIGN contributes to elimination of mannosylated ligands but does not participate in hepatic clearance of P. falciparum-infected erythrocytes.Hepatic cell populations play an important role during the malaria life cycle. L-SIGN, a homologue of DC-SIGN, mediating leukocyte and pathogen binding, is selectively expressed on liver endothelial cells. Here, we present evidence that L-SIGN acts as an endocytic cell surface receptor. However, P. falciparum-infected erythrocytes did not cytoadhere to L-SIGN. Thus, L-SIGN contributes to elimination of mannosylated ligands but does not participate in hepatic clearance of P. falciparum-infected erythrocytes.
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    Journal Title
    Parasitology Research
    Volume
    96
    Issue
    4
    Publisher URI
    http://www.springer.com/biomed/medical+microbiology/journal/436
    DOI
    https://doi.org/10.1007/s00436-005-1360-4
    Subject
    Microbiology
    Veterinary sciences
    Medical microbiology
    Publication URI
    http://hdl.handle.net/10072/27821
    Collection
    • Journal articles

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