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dc.contributor.authorN. Peart, Jasonen_US
dc.contributor.authorJ. Gross, Garretten_US
dc.date.accessioned2017-05-03T13:03:45Z
dc.date.available2017-05-03T13:03:45Z
dc.date.issued2004en_US
dc.date.modified2009-12-21T03:16:20Z
dc.identifier.issn05315565en_US
dc.identifier.doi10.1016/j.exger.2004.03.038en_AU
dc.identifier.urihttp://hdl.handle.net/10072/27832
dc.description.abstractAging is often associated with decreased myocardial ischemic tolerance. We recently reported that chronic preconditioning produced by continuous exposure to morphine affords a profound cardioprotective phenotype in young mice. In this study, we determined if chronic exposure to morphine retained its ability to precondition the myocardium in the young or aged heart. Young (10-14 weeks) or aged (24-26 months) C57/BL6 mice were untreated, administered morphine acutely (30 卩, or implanted with a morphine pellet (75 mg) for 5 days prior to heart isolation and perfusion. Following equilibration, perfused hearts were subjected to 25 min ischemia and 45 min reperfusion. Untreated hearts from both young and aged mice displayed marked contractile dysfunction and LDH release following reperfusion. Acute infusion of morphine improved recovery of end-diastolic pressure and developed pressure in young (P<0.05 vs. untreated) but not senescent hearts. Hearts from mice exposed to morphine for 5 days displayed a further improvement in post-ischemic contractile function (P<0.05 vs. acute treatment), and a marked reduction in post-ischemic LDH efflux (P<0.05 vs. untreated) in both young and senescent hearts. These data demonstrate that aged hearts maintain the ability to be preconditioned by chronic exposure to morphine in the absence of acute protection.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_AU
dc.languageEnglishen_US
dc.language.isoen_AU
dc.publisherElsevier Incen_US
dc.publisher.placeNew York, NYen_US
dc.publisher.urihttp://www.sciencedirect.com/science/journal/05315565en_AU
dc.relation.ispartofpagefrom1021en_US
dc.relation.ispartofpageto1026en_US
dc.relation.ispartofissue7en_US
dc.relation.ispartofjournalExperimental Gerontologyen_US
dc.relation.ispartofvolume39en_US
dc.subject.fieldofresearchcode320503en_US
dc.titleChronic exposure to morphine produces a marked cardioprotective phenotype in aged mouse heartsen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.date.issued2004
gro.hasfulltextNo Full Text


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