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dc.contributor.authorN. Peart, Jasonen_US
dc.contributor.authorJ. Gross, Garretten_US
dc.date.accessioned2017-05-03T13:03:39Z
dc.date.available2017-05-03T13:03:39Z
dc.date.issued2004en_US
dc.date.modified2009-12-21T03:16:23Z
dc.identifier.issn00097322en_US
dc.identifier.doi10.1161/01.CIR.0000121422.85989.BDen_AU
dc.identifier.urihttp://hdl.handle.net/10072/27833
dc.description.abstractBackground- Morphine and other opioids continue to be used as the major treatment for acute pain both before and after surgery. In this regard, much research has focused on the mechanisms of morphine tolerance and dependence in the central nervous system; however, few studies have examined the effect of morphine on peripheral organs, such as the heart, in morphine-tolerant animals. Here, we examine the effect of tolerance to the analgesic effect of morphine on ischemic tolerance in mice after prolonged morphine exposure and withdrawal. Methods and Results- Male C57/BL6 mice were implanted subcutaneously with either placebo or morphine pellets (25 or 75 mg). After prolonged exposure to and/or withdrawal from morphine or placebo, the hearts were excised and subjected to 25 minutes of ischemia and 45 minutes of reperfusion. Morphine-tolerant mice exhibited a markedly improved functional recovery compared with placebo and mice subjected to acute morphine. Lactate dehydrogenase release was also significantly reduced. The protection observed was equieffective 48 hours after withdrawal of pellet, whereas the onset of protection preceded analgesic tolerance. Conclusions- These data demonstrate that chronic exposure to morphine unexpectedly results in a profound and persistent cardioprotective phenotype.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_AU
dc.languageEnglishen_US
dc.language.isoen_AU
dc.publisherLippincott, Williams and Wilkinsen_US
dc.publisher.placeUSAen_US
dc.publisher.urihttp://circ.ahajournals.org/en_AU
dc.relation.ispartofpagefrom1219en_US
dc.relation.ispartofpageto1222en_US
dc.relation.ispartofjournalCirculation.en_US
dc.relation.ispartofvolume109en_US
dc.subject.fieldofresearchcode320503en_US
dc.titleMorphine-tolerant mice exhibit a profound and persistent cardioprotective phenotype.en_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.rights.copyrightCopyright 2004 Lippincott, Williams & Wilkins. Self-archiving of the author-manuscript version is not yet supported by this publisher. Please refer to the journal link for access to the definitive, published version or contact the author[s] for more information.en_AU
gro.date.issued2004
gro.hasfulltextNo Full Text


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