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dc.contributor.authorAdams, Y
dc.contributor.authorSmith, SL
dc.contributor.authorSchwartz-Albiez, R
dc.contributor.authorAndrews, KT
dc.date.accessioned2017-05-03T16:57:41Z
dc.date.available2017-05-03T16:57:41Z
dc.date.issued2005
dc.date.modified2009-12-21T03:16:59Z
dc.identifier.issn0932-0113
dc.identifier.doi10.1007/s00436-005-1426-3
dc.identifier.urihttp://hdl.handle.net/10072/27838
dc.description.abstractCarbohydrates are implicated in many of the invasive and adhesive interactions that occur between Plasmodium falciparum malaria parasites and human host cells, including invasion of sporozoites into hepatocytes, entry of merozoites into new host erythrocytes during asexual blood-stage replication, adhesion of infected erythrocytes to uninfected erythrocytes (rosetting) and to a number of host endothelial receptors including ICAM-1, CD36 and chondroitin-4-sulphate. In addition to increasing our understanding of host-parasite interactions, the investigation of carbohydrates with differing levels and patterns of sulphation as inhibitors may contribute to the development of novel therapeutics targeting malaria. Here we show that three polysaccharides derived from seaweed (carrageenans) with differing sulphation levels and patterns can inhibit the in vitro erythrocytic invasion and growth of both drug sensitive and drug resistant P. falciparum lines and the adhesion of parasitized erythrocytes to the human glycoprotein CD36.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherSpringer-Verlag
dc.publisher.placeGermany
dc.publisher.urihttp://www.springer.com/biomed/medical+microbiology/journal/436
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom290
dc.relation.ispartofpageto294
dc.relation.ispartofissue4
dc.relation.ispartofjournalParasitology Research
dc.relation.ispartofvolume97
dc.rights.retentionY
dc.subject.fieldofresearchMicrobiology
dc.subject.fieldofresearchVeterinary sciences
dc.subject.fieldofresearchMedical microbiology
dc.subject.fieldofresearchcode3107
dc.subject.fieldofresearchcode3009
dc.subject.fieldofresearchcode3207
dc.titleCarrageenans inhibit the in vitro growth of Plasmodium falciparum and cytoadhesion to CD36
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.date.issued2005
gro.hasfulltextNo Full Text
gro.griffith.authorAndrews, Katherine T.


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