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dc.contributor.authorPinzon-Charry, A
dc.contributor.authorMaxwell, T
dc.contributor.authorPrato, S
dc.contributor.authorFurnival, C
dc.contributor.authorSchmidt, C
dc.contributor.authorLopez, JA
dc.date.accessioned2017-05-03T16:58:40Z
dc.date.available2017-05-03T16:58:40Z
dc.date.issued2005
dc.date.modified2011-06-28T06:44:33Z
dc.identifier.issn1476-5586
dc.identifier.urihttp://hdl.handle.net/10072/27869
dc.description.abstractDendritic cells (DC) have been implicated in the defective function of the immune system during cancer progression. We have demonstrated that patients with cancer have fewer myeloid (CD11c+) and plasmacytoid (CD123hi) DC and a concurrent accumulation of CD11c-CD123- immature cells expressing HLA-DR (DR+IC). Notably, DR+IC from cancer patients have a reduced capacity to stimulate allogeneic T-cells. DR+IC are also present in healthy donors, albeit in smaller numbers. In this study, we assessed whether DR+IC could have an impact on the immune response by comparing their function with DC counterparts. For this purpose, DR+IC and DC were purified and tested in the presentation of antigens through major histocompatibility complex (MHC) II and MHC-I molecules. DR+IC were less efficient than DC at presenting antigens to T-cells. DR+IC induced a limited activation of T-cells, eliciting poor T-helper (Th) 1 and preferentially inducing Th2-biased responses. Importantly, despite DR+IC's poor responsiveness to inflammatory factors, in samples from healthy volunteers and breast cancer patients, CD40 ligation induced phenotypic maturation and interleukin 12 secretion, in turn generating more efficient T-cell responses. These data underscore the importance of inefficient antigen presentation as a mechanism for tumor evasion and suggest an approach to improve the efficacy of DC-based immunotherapy for cancer.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.format.extent582768 bytes
dc.format.mimetypeapplication/pdf
dc.languageEnglish
dc.language.isoeng
dc.publisherNeoplasia Press
dc.publisher.placeUntied States of America
dc.publisher.urihttp://www.neoplasia.com/abstract.php?msid=696
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom1123
dc.relation.ispartofpageto1132
dc.relation.ispartofissue3
dc.relation.ispartofjournalNeoplasia
dc.relation.ispartofvolume35
dc.rights.retentionY
dc.subject.fieldofresearchImmunology not elsewhere classified
dc.subject.fieldofresearchClinical Sciences
dc.subject.fieldofresearchcode110799
dc.subject.fieldofresearchcode1103
dc.titleHLA-DR+ Immature Cells Exhibit Reduced Antigen-Presenting Cell Function But Respond to CD40 Stimulation
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.rights.copyright© 2005 Neoplasia Press. The attached file is reproduced here in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version.
gro.date.issued2005
gro.hasfulltextFull Text
gro.griffith.authorLopez Ramirez, Alejandro
gro.griffith.authorPinzon-Charry, Alberto


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