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dc.contributor.authorNeuzill, J
dc.contributor.authorAndera, L
dc.contributor.authorGabrielli, B
dc.contributor.editorSluyser, M.
dc.date.accessioned2017-05-03T16:59:17Z
dc.date.available2017-05-03T16:59:17Z
dc.date.issued2005
dc.date.modified2009-12-22T07:46:40Z
dc.identifier.isbn9781402033032
dc.identifier.doi10.1007/1-4020-3302-8_12
dc.identifier.urihttp://hdl.handle.net/10072/27932
dc.description.abstractHistone deacetylas inhibitors (HDIs) are a novel prospective group of potential anti-cancer agents, some of them being tested in a clinical setting. The major mode of action of these compounds is inhibition of the cell cycle transition and, consequently, differential regulation of a number of genes necessary for cell proliferation, while favouring expression of genes rather associated with anti-proliferative pathways and with cell death signalling. This implies a possible role of HDIs in adjuvant treatment of tumours resistant to other agents, operating via a different molecular mechanism. The TNF-related apoptosis-inducing ligant (TRAIL) is a promising immunological inducer of apoptosis efficient against a variety of tumours with a remarkably selective mode of action. However, some malignancies are resistant to TRAIL treatment. In this paper, we review our current knowledge on HDI-mediated sensitisation of TRAIL-non-responsive tumours to this apoptogen and suggest a future clinical potential of HDIs and TRAIL in cancer management.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherSpringer
dc.publisher.placeDordrecht
dc.relation.ispartofbooktitleApplication of apoptosis to cancer treatment
dc.relation.ispartofchapter12
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom271
dc.relation.ispartofpageto292
dc.rights.retentionY
dc.subject.fieldofresearchMulti-Disciplinary
dc.subject.fieldofresearchcode999999
dc.titleHistone deacetylase inhibitors as a treatment of TRAIL-resistant cancers
dc.typeBook chapter
dc.type.descriptionB1 - Chapters
dc.type.codeB - Book Chapters
gro.date.issued2005
gro.hasfulltextNo Full Text
gro.griffith.authorNeuzil, Jiri
gro.griffith.authorGabrielli, Brian


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