Total Synthesis of Spongistatin 1 (Altohyrtin A): A Tale of Ten Aldols
A review on the total synthesis of spongistatin 1/altohyrtin A, an extremely rare marine macrolide with a seductively complex structure in combination with displaying promising anticancer properties. Topics covered include the retrosynthetic anal.; the AB- and CD-spiroacetal subunit; the Northern and Southern hemisphere; Wittig coupling of the Northern and Southern hemispheres; and final steps of structure-activity relationships.
Strategies and Tactics in Organic Synthesis
Self-archiving is not yet supported by this publisher. Please refer to the publisher's website or contact the author(s) for more information.