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dc.contributor.authorGreen, Michael
dc.contributor.authorGandhi, Maher
dc.contributor.authorCamilleri, Emily
dc.contributor.authorMarlton, Paula
dc.contributor.authorLea, Rodney
dc.contributor.authorGriffiths, Lyn
dc.date.accessioned2017-05-03T12:16:14Z
dc.date.available2017-05-03T12:16:14Z
dc.date.issued2009
dc.date.modified2010-06-11T04:26:21Z
dc.identifier.issn01452126
dc.identifier.doi10.1016/j.leukres.2008.09.007
dc.identifier.urihttp://hdl.handle.net/10072/28047
dc.description.abstractThe t(14;18)(q21;q34) BCL2 translocation is a common genetic alteration in follicular and diffuse large Bcell lymphoma. However, it is not invariably associated with BCL2 gene overexpression due to undefined mechanisms that regulate expression from the proximal immunoglobulin heavy-chain (IgH) promoter. The BACH2 transcriptional repressor is able to modulate activity of this promoter. Here we have shown that, in tumor samples with BCL2 translocation, those with high levels of BACH2 had significantly lower BCL2 transcript abundance compared to those with low levels of BACH2. This indicates that BACH2 may be partially responsible for regulation of BCL2 expression from the t(14;18)(q21;q34) translocation.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.format.extent161551 bytes
dc.format.mimetypeapplication/pdf
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier
dc.publisher.placeSt. Louis, USA
dc.publisher.urihttp://linkinghub.elsevier.com/retrieve/pii/S014521260800413X
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom731
dc.relation.ispartofpageto734
dc.relation.ispartofjournalLeukemia Research
dc.relation.ispartofvolume33
dc.rights.retentionY
dc.subject.fieldofresearchClinical Sciences
dc.subject.fieldofresearchcode1103
dc.titleHigh levels of BACH2 associated with lower levels of BCL2 transcript abundance in t(14;18)(q21;q34) translocation positive non-Hodgkin’s lymphoma
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.facultyGriffith Health, School of Medical Science
gro.rights.copyright© 2009 Elsevier. This is the author-manuscript version of this paper. Reproduced in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version.
gro.date.issued2009
gro.hasfulltextFull Text
gro.griffith.authorGriffiths, Lyn
gro.griffith.authorLea, Rodney A.
gro.griffith.authorCamilleri, Emily T.
gro.griffith.authorGreen, Michael R.
gro.griffith.authorGandhi, Maher K.


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