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  • ClC-5 A chloride channel with multiple roles in renal tubular albumin uptake

    Author(s)
    Hryciw, Deanne H
    Ekberg, Jenny
    Pollock, Carol A
    Poronnik, Philip
    Griffith University Author(s)
    Ekberg, Jenny A.
    Hryciw, Deanne
    Year published
    2006
    Metadata
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    Abstract
    ClC-5 is a chloride (Cl-) channel expressed in renal tubules and is critical for normal tubular function. Loss of function nonsense or missense mutations in ClC-5 are associated with Dent's disease, a condition in which patients present with low molecular weight (LMW) proteinuria (including albuminuria), hypercalciuria and nephrolithiasis. Several key studies in ClC-5 knockout mice have shown that the proteinuria results from defective tubular reabsorption of proteins. ClC-5 is typically regarded as an intracellular Cl- channel and thus the defect in this receptor-mediated uptake pathway was initially attributed to the failure ...
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    ClC-5 is a chloride (Cl-) channel expressed in renal tubules and is critical for normal tubular function. Loss of function nonsense or missense mutations in ClC-5 are associated with Dent's disease, a condition in which patients present with low molecular weight (LMW) proteinuria (including albuminuria), hypercalciuria and nephrolithiasis. Several key studies in ClC-5 knockout mice have shown that the proteinuria results from defective tubular reabsorption of proteins. ClC-5 is typically regarded as an intracellular Cl- channel and thus the defect in this receptor-mediated uptake pathway was initially attributed to the failure of the early endosomes to acidify correctly. ClC-5 was postulated to play a key role in transporting the Cl- ions required to compensate for the movement of H+ during endosomal acidification. However, more recent studies suggest additional roles for ClC-5 in the endocytosis of albumin. ClC-5 is now known to be expressed at low levels at the cell surface and appears to be a key component in the assembly of the macromolecular complex involved in protein endocytosis. Furthermore, mutations in ClC-5 affect the trafficking of v-H+-ATPase and result in decreased expression of the albumin receptor megalin/cubulin. Thus, the expression of ClC-5 at the cell surface as well as its presence in endosomes appears to be essential for normal protein uptake by the renal proximal tubule.
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    Journal Title
    The International Journal of Biochemistry and Cell Biology
    Volume
    38
    Issue
    7
    DOI
    https://doi.org/10.1016/j.biocel.2005.09.009
    Subject
    Biochemistry and cell biology
    Cell metabolism
    Medical biochemistry and metabolomics
    Medical physiology
    Publication URI
    http://hdl.handle.net/10072/28094
    Collection
    • Journal articles

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