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  • Neuronal voltage-gated sodium channel subtypes: Key roles in inflammatory and neuropathic pain

    Author(s)
    Ekberg, J
    Adams, DJ
    Griffith University Author(s)
    Ekberg, Jenny A.
    Year published
    2006
    Metadata
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    Abstract
    Voltage-gated sodium channels (VGSCs) play an important role in neuronal excitability. Regulation of VGSC activity is a complex phenomenon that occurs at multiple levels in the cell, including transcriptional regulation, post-translational modification and membrane insertion and retrieval. Multiple VGSC subtypes exist that vary in their biophysical and pharmacological properties and tissue distribution. Any alteration of the VGSC subtype profile of a neuron or the mechanisms that regulate VGSC activity can cause significant changes in neuronal excitability. Inflammatory and neuropathic pain states are characterised by ...
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    Voltage-gated sodium channels (VGSCs) play an important role in neuronal excitability. Regulation of VGSC activity is a complex phenomenon that occurs at multiple levels in the cell, including transcriptional regulation, post-translational modification and membrane insertion and retrieval. Multiple VGSC subtypes exist that vary in their biophysical and pharmacological properties and tissue distribution. Any alteration of the VGSC subtype profile of a neuron or the mechanisms that regulate VGSC activity can cause significant changes in neuronal excitability. Inflammatory and neuropathic pain states are characterised by alterations in VGSC subtype composition and activity in sensory neurons. This review focuses on the VGSC subtypes involved in such pain states.
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    Journal Title
    The International Journal of Biochemistry and Cell Biology
    Volume
    38
    Issue
    12
    DOI
    https://doi.org/10.1016/j.biocel.2006.06.008
    Subject
    Biochemistry and cell biology
    Cell neurochemistry
    Medical biochemistry and metabolomics
    Medical physiology
    Publication URI
    http://hdl.handle.net/10072/28095
    Collection
    • Journal articles

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