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  • Expression profiling in monozygotic twins discordant for bipolar disorder reveals dysregulation of the WNT signalling pathway

    Author(s)
    Matigian, N.
    Windus, L.
    Smith, H.
    Filippich, C.
    Pantelis, C.
    McGrath, J.
    Mowry, B.
    Hayward, N.
    Griffith University Author(s)
    McGrath, John J.
    Year published
    2007
    Metadata
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    Abstract
    To identify genes dysregulated in bipolar disorder (BD1), we carried out global gene expression profiling using whole-genome microarrays. To minimize genetic variation in gene expression levels between cases and controls, we compared expression profiles in lymphoblastoid cell lines from monozygotic twin pairs discordant for the disease. We identified 82 genes that were differentially expressed by greater than or equal to1.3-fold in three BD1 cases compared to their co-twins, and which were statistically (Pless than or equal to0.05) differentially expressed between the groups of BD1 cases and controls. Using quantitative ...
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    To identify genes dysregulated in bipolar disorder (BD1), we carried out global gene expression profiling using whole-genome microarrays. To minimize genetic variation in gene expression levels between cases and controls, we compared expression profiles in lymphoblastoid cell lines from monozygotic twin pairs discordant for the disease. We identified 82 genes that were differentially expressed by greater than or equal to1.3-fold in three BD1 cases compared to their co-twins, and which were statistically (Pless than or equal to0.05) differentially expressed between the groups of BD1 cases and controls. Using quantitative reverse transcriptase-polymerase chain reaction, we confirmed the differential expression of some of these genes, including: KCNK1, MAL, PFN2, TCF7, PGK1 and PI4KCB, in at least two of the twin pairs. In contrast to the findings of a previous study by Kakiuchi and colleagues with similar discordant BD1 twin design, our data do not support the dysregulation of XBP1 and HSPA5. From pathway and gene ontology analysis, we identified upregulation of the WNT signalling pathway and the biological process of apoptosis. The differentially regulated genes and pathways identified in this study may provide insights into the biology of BD1.
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    Journal Title
    Molecular Psychiatry
    Volume
    12
    Issue
    9
    DOI
    https://doi.org/10.1038/sj.mp.4001998
    Subject
    Psychiatry (incl. Psychotherapy)
    Biological Sciences
    Medical and Health Sciences
    Psychology and Cognitive Sciences
    Publication URI
    http://hdl.handle.net/10072/28096
    Collection
    • Journal articles

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