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dc.contributor.authorMatigian, N.
dc.contributor.authorWindus, L.
dc.contributor.authorSmith, H.
dc.contributor.authorFilippich, C.
dc.contributor.authorPantelis, C.
dc.contributor.authorMcGrath, J.
dc.contributor.authorMowry, B.
dc.contributor.authorHayward, N.
dc.date.accessioned2017-05-03T16:58:07Z
dc.date.available2017-05-03T16:58:07Z
dc.date.issued2007
dc.date.modified2010-01-07T02:17:46Z
dc.identifier.issn13594184
dc.identifier.doi10.1038/sj.mp.4001998
dc.identifier.urihttp://hdl.handle.net/10072/28096
dc.description.abstractTo identify genes dysregulated in bipolar disorder (BD1), we carried out global gene expression profiling using whole-genome microarrays. To minimize genetic variation in gene expression levels between cases and controls, we compared expression profiles in lymphoblastoid cell lines from monozygotic twin pairs discordant for the disease. We identified 82 genes that were differentially expressed by greater than or equal to1.3-fold in three BD1 cases compared to their co-twins, and which were statistically (Pless than or equal to0.05) differentially expressed between the groups of BD1 cases and controls. Using quantitative reverse transcriptase-polymerase chain reaction, we confirmed the differential expression of some of these genes, including: KCNK1, MAL, PFN2, TCF7, PGK1 and PI4KCB, in at least two of the twin pairs. In contrast to the findings of a previous study by Kakiuchi and colleagues with similar discordant BD1 twin design, our data do not support the dysregulation of XBP1 and HSPA5. From pathway and gene ontology analysis, we identified upregulation of the WNT signalling pathway and the biological process of apoptosis. The differentially regulated genes and pathways identified in this study may provide insights into the biology of BD1.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherNature Publishing Group
dc.publisher.placeUK
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom815
dc.relation.ispartofpageto825
dc.relation.ispartofissue9
dc.relation.ispartofjournalMolecular Psychiatry
dc.relation.ispartofvolume12
dc.rights.retentionY
dc.subject.fieldofresearchPsychiatry (incl. Psychotherapy)
dc.subject.fieldofresearchBiological Sciences
dc.subject.fieldofresearchMedical and Health Sciences
dc.subject.fieldofresearchPsychology and Cognitive Sciences
dc.subject.fieldofresearchcode110319
dc.subject.fieldofresearchcode06
dc.subject.fieldofresearchcode11
dc.subject.fieldofresearchcode17
dc.titleExpression profiling in monozygotic twins discordant for bipolar disorder reveals dysregulation of the WNT signalling pathway
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.date.issued2007
gro.hasfulltextNo Full Text
gro.griffith.authorMcGrath, John J.


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