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dc.contributor.authorYe, Xianghai
dc.contributor.authorBrown, Stewart R.
dc.contributor.authorNones, Katia
dc.contributor.authorCoutinho, Luiz L.
dc.contributor.authorDekkers, Jack C. M.
dc.contributor.authorLamont, Susan J.
dc.date.accessioned2018-01-11T01:52:16Z
dc.date.available2018-01-11T01:52:16Z
dc.date.issued2007
dc.date.modified2010-01-07T06:45:03Z
dc.identifier.issn0999193X
dc.identifier.doi10.1051/gse:2006029
dc.identifier.urihttp://hdl.handle.net/10072/28109
dc.description.abstractMyostatin is a negative regulator of skeletal muscle growth. We evaluated effects of myostatin polymorphisms in three elite commercial broiler chicken lines on mortality, growth, feed conversion efficiency, ultrasound breast depth, breast percentage, eviscerated carcass weight, leg defects, blood oxygen level, and hen antibody titer to infectious bursal disease virus vaccine. Progeny mean data adjusted for fixed and mate effects and DNA from 100 sires per line were used. Single nucleotide polymorphisms (SNPs) of the myostatin gene segregating in these lines were identified by designing specific primers, amplifying individual DNA in each line by polymerase chain reaction, cloning, sequencing and aligning the corresponding products. Individual sires were genotyped for five identified SNPs which contributed to eight haplotypes. Frequencies of SNP alleles and haplotypes differed between lines. Using the allele substitution effect model, the myostatin SNPs were found to have significant (P < 0.031) associations with growth, mortality, blood oxygen and hen antibody titer to infectious bursal disease virus vaccine, although the associations were not often consistent across lines. These results suggest that the myostatin gene has pleiotropic effects on broiler performance.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherBioMed Central Ltd.
dc.publisher.placeUK
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom73
dc.relation.ispartofpageto89
dc.relation.ispartofissue1
dc.relation.ispartofjournalGenetics Selection Evolution
dc.relation.ispartofvolume37
dc.rights.retentionY
dc.subject.fieldofresearchAgricultural Biotechnology not elsewhere classified
dc.subject.fieldofresearchBiological Sciences
dc.subject.fieldofresearchTechnology
dc.subject.fieldofresearchcode100199
dc.subject.fieldofresearchcode06
dc.subject.fieldofresearchcode10
dc.titleAssociations of myostatin gene polymorphisms with performance and mortality traits in broiler chickens
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dc.description.versionVersion of Record (VoR)
gro.rights.copyright© INRA, EDP Sciences, 2006
gro.date.issued2007
gro.hasfulltextFull Text
gro.griffith.authorNones, Katia


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