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dc.contributor.authorMcGrath, John
dc.contributor.authorScragg, Robert
dc.contributor.authorChant, David
dc.contributor.authorEyles, Darryl
dc.contributor.authorBurne, Thomas
dc.contributor.authorObradovic, Darja
dc.date.accessioned2017-05-03T16:58:03Z
dc.date.available2017-05-03T16:58:03Z
dc.date.issued2007
dc.date.modified2010-01-07T06:45:27Z
dc.identifier.issn02515350
dc.identifier.doi10.1159/000108918
dc.identifier.urihttp://hdl.handle.net/10072/28118
dc.description.abstractBackground: Animal studies and in vitro experiments indicate that vitamin D is involved in a diverse range of neurobiological functions. We had the opportunity to examine the relationship between serum 25-hydroxyvitamin D3 [25(OH)D] levels and performance on various cognitive tasks, based on a large, representative community sample. Methods: Three age groups were available from the population-based NHANES III survey: adolescent group (n = 1,676, age range 12-17 years), adult group (n = 4,747, 20-60 years), elderly group (n = 4,809, 60-90 years). The associations between eight psychometric measures and serum 25(OH)D were assessed. Results: In the adolescent and adult groups, none of the psychometric measures were associated with 25(OH)D levels. In the elderly group there was a significant difference between 25(OH)D quintiles performance on a learning and memory task; however, those with the highest quintile of 25(OH)D were most impaired on the task, contrary to the hypotheses. Conclusion: Lower 25(OH)D levels were not associated with impaired performance on various psychometric measures. While it remains to be seen if chronic exposure to low 25(OH)D levels alters brain function in the long term, this cross-sectional study suggests that 25(OH)D levels do not influence neurocognitive performance.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherS.Karger
dc.publisher.placeSwitzerland
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom49
dc.relation.ispartofpageto54
dc.relation.ispartofissue1-2
dc.relation.ispartofjournalNeuroepidemiology
dc.relation.ispartofvolume29
dc.rights.retentionY
dc.subject.fieldofresearchPsychiatry (incl. Psychotherapy)
dc.subject.fieldofresearchNeurosciences
dc.subject.fieldofresearchPublic Health and Health Services
dc.subject.fieldofresearchcode110319
dc.subject.fieldofresearchcode1109
dc.subject.fieldofresearchcode1117
dc.titleNo association between serum 25-hydroxyvitamin D3 level and performance on psychometric tests in NHANES III
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.date.issued2007
gro.hasfulltextNo Full Text
gro.griffith.authorMcGrath, John J.


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