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dc.contributor.authorLi, Li
dc.contributor.authorPettit, Allison R
dc.contributor.authorGregory, Laura S
dc.contributor.authorForwood, Mark R
dc.date.accessioned2017-05-03T17:00:39Z
dc.date.available2017-05-03T17:00:39Z
dc.date.issued2006
dc.date.modified2010-01-08T06:25:25Z
dc.identifier.issn1359-6101
dc.identifier.doi10.1016/j.cytogfr.2006.01.005
dc.identifier.urihttp://hdl.handle.net/10072/28155
dc.description.abstractIt is well established that prostaglandins are essential mediators of bone resorption and formation. In the early 1990s, it was discovered that enzymatic reactions producing prostaglandins were regulated by two cyclooxygenase enzymes, one producing prostaglandins constitutively in tissues like the stomach, prostaglandin endoperoxide H synthase-1 (PGHS-1 or COX-1), and another induced by mitogens or inflammatory mediators (PGHS-2 or COX-2). This neat distinction has not been maintained because both enzymes act in different cell systems to provide physiological signaling, constitutively or by induction under certain conditions. For example, the regulation patterns of PGHS-1 and PGHS-2 are distinct, but the evidence shows that PGHS-2 functions constitutively in the skeleton. PGHS-2 has quickly been established, therefore, as a key regulator of bone biology, capable of rapid and transient expression in bone cells, and mediating osteoclastogenesis, mechanotransduction, bone formation and fracture repair. The goal of this review is to summarize the current state of our knowledge of PGHS regulation of bone metabolism and to identify some of the key unresolved challenges and questions that require further study.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier
dc.publisher.placeUnited Kingdom
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom203
dc.relation.ispartofpageto216
dc.relation.ispartofissue3
dc.relation.ispartofjournalCytokine and Growth Factor Reviews
dc.relation.ispartofvolume17
dc.rights.retentionY
dc.subject.fieldofresearchBiochemistry and cell biology
dc.subject.fieldofresearchClinical sciences
dc.subject.fieldofresearchcode3101
dc.subject.fieldofresearchcode3202
dc.titleRegulation of bone biology by prostaglandin endoperoxide H synthases (PGHS): A rose by any other name. . .
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.date.issued2006
gro.hasfulltextNo Full Text
gro.griffith.authorForwood, Mark R.


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