Show simple item record

dc.contributor.authorEsposito, G.
dc.contributor.authorVitale, A.
dc.contributor.authorLeitjen, F.
dc.contributor.authorStrik, A.
dc.contributor.authorKoonen-Reemst, A. B.
dc.contributor.authorYurttas, P.
dc.contributor.authorRobben, T. A.
dc.contributor.authorCoonrod, S.
dc.contributor.authorGossen, J.
dc.date.accessioned2019-04-05T04:55:58Z
dc.date.available2019-04-05T04:55:58Z
dc.date.issued2007
dc.date.modified2010-01-11T07:55:02Z
dc.identifier.issn03037207
dc.identifier.doi10.1016/j.mce.2007.05.005
dc.identifier.urihttp://hdl.handle.net/10072/28191
dc.description.abstractPeptidylarginine deiminase 6 (PAD6) is an enzyme that is uniquely expressed in male and female germ cells. To study the function of this enzyme in vivo we generated mice deficient for PAD6. Here we show that inactivation of the PAD6 gene in mice leads to female infertility whereas male fertility is not affected. The absence of the PAD6 protein and consequently absence of citrullination activity in oocytes results in dispersal of the cytoskeletal sheets in oocytes, indicating an essential role of these germ cell-specific structures in zygote/embryo development. PAD6 deficient mice do not show any other overt phenotype. Thus, we identify citrullination as a new regulator of fertility.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoen_AU
dc.publisherElsevier
dc.publisher.placeIreland
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom25
dc.relation.ispartofpageto31
dc.relation.ispartofissue1-2
dc.relation.ispartofjournalMolecular and Cellular Endocrinology
dc.relation.ispartofvolume273
dc.rights.retentionY
dc.subject.fieldofresearchCell Development, Proliferation and Death
dc.subject.fieldofresearchBiological Sciences
dc.subject.fieldofresearchAgricultural and Veterinary Sciences
dc.subject.fieldofresearchMedical and Health Sciences
dc.subject.fieldofresearchcode060103
dc.subject.fieldofresearchcode06
dc.subject.fieldofresearchcode07
dc.subject.fieldofresearchcode11
dc.titlePeptidylarginine deiminase (PAD) 6 is essential for oocyte cytoskeletal sheet formation and female fertility
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dcterms.licensehttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.description.versionPost-print
gro.rights.copyright© 2007 Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International Licence which permits unrestricted, non-commercial use, distribution and reproduction in any medium, providing that the work is properly cited.
gro.date.issued2007
gro.hasfulltextNo Full Text
gro.griffith.authorVitale, Alejandra M.


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

  • Journal articles
    Contains articles published by Griffith authors in scholarly journals.

Show simple item record