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  • The Macrophage Inducible c-type lectin, Mincle, is an essential component of the innate-immune response to Candida albicans

    Author(s)
    Wells, Christine A
    Salvage-Jones, Judith A
    Li, Xin
    Hitchens, Kelly
    Butcher, Suzanne
    Murray, Rachael Z
    Beckhouse, Anthony G
    Lo, Yu-Lan-Sandra
    Manzanero, Silvia
    Cobbold, Christian
    Schroder, Kate
    Ma, Bo
    Orr, Sally
    Stewart, Lauren
    Lebus, Daniel
    Sobieszczuk, Peter
    Hume, David A
    Stow, Jennifer
    Blanchard, Helen
    Ashman, Robert B
    Griffith University Author(s)
    Cobbold, Christian J.
    Year published
    2008
    Metadata
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    Abstract
    The recognition of carbohydrate moieties by cells of the innate immune system is emerging as an essential element in anti-fungal immunity, but few carbohydrate receptors have been characterised, despite the number and diversity of lectins expressed by innate immune cells. We demonstrate a novel role for the c-type lectin Mincle in macrophage responses to C. albicans. Mincle was observed to localise in the phagocytic cup of macrophages in response to a range of stimuli. Loss of Mincle reduced macrophage TNF production both in vivo and in vitro, but did not alter the number of Candida yeast phagocytised. Mice lacking Mincle ...
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    The recognition of carbohydrate moieties by cells of the innate immune system is emerging as an essential element in anti-fungal immunity, but few carbohydrate receptors have been characterised, despite the number and diversity of lectins expressed by innate immune cells. We demonstrate a novel role for the c-type lectin Mincle in macrophage responses to C. albicans. Mincle was observed to localise in the phagocytic cup of macrophages in response to a range of stimuli. Loss of Mincle reduced macrophage TNF production both in vivo and in vitro, but did not alter the number of Candida yeast phagocytised. Mice lacking Mincle showed a significantly increased susceptibility to systemic candidiasis. Thus Mincle contributes a novel and non-redundant role in the induction of inflammatory signalling in response to C. albicans infection.
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    Conference Title
    JOURNAL OF IMMUNOLOGY
    Volume
    180
    Issue
    11
    Publisher URI
    http://www.glycobiology.org/
    Subject
    Immunology
    Publication URI
    http://hdl.handle.net/10072/28193
    Collection
    • Conference outputs

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